Shaoqiong Liu1, Xia Liu1, Juan Li1, Hong Zhou1, Michael J Carr2,3, Zhenjie Zhang1, Weifeng Shi1. 1. Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Province, Taishan Medical University, Taian, China. 2. Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan. 3. National Virus Reference Laboratory, School of Medicine, University College Dublin, Dublin 4, Ireland.
Abstract
Long noncoding RNAs (lncRNAs) represent a key class of cellular regulators, involved in the modulation and control of multiple biological processes. Distinct classes of lncRNAs are now known to be induced by host cytokines following viral infections. Current evidence demonstrates that lncRNAs play essential roles at the host-pathogen interface regulating viral infections by either innate immune responses at various levels including activation of pathogen recognition receptors or by epigenetic, transcriptional, and posttranscriptional effects. We review the newly described mechanisms underlying the interactions between lncRNAs, cytokines, and metabolites differentially expressed following viral infections; we highlight the regulatory networks of host antiviral responses and emphasize the need for interdisciplinary research between lncRNA biology and immunology to deepen understanding of viral pathogenesis.
Long noncoding RNAs (lpan class="Gene">ncRNAs) represent a key class of cellular regulators, involved in the modulation and control of multiple biological processes. Distinct classes of lpan class="Gene">ncRNAs are now known to be induced by host cytokines following viral infections. Current evidence demonstrates that lncRNAs play essential roles at the host-pathogen interface regulating viral infections by either innate immune responses at various levels including activation of pathogen recognition receptors or by epigenetic, transcriptional, and posttranscriptional effects. We review the newly described mechanisms underlying the interactions between lncRNAs, cytokines, and metabolites differentially expressed following viral infections; we highlight the regulatory networks of host antiviral responses and emphasize the need for interdisciplinary research between lncRNA biology and immunology to deepen understanding of viral pathogenesis.
Authors: Izabela Łasińska; Tomasz Kolenda; Kacper Guglas; Magda Kopczyńska; Joanna Sobocińska; Anna Teresiak; Norbert Oksza Strzelecki; Katarzyna Lamperska; Andrzej Mackiewicz; Jacek Mackiewicz Journal: J Pers Med Date: 2020-09-16