Literature DB >> 3101677

Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450.

J Capdevila, P Yadagiri, S Manna, J R Falck.   

Abstract

Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.

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Year:  1986        PMID： 3101677     DOI： 10.1016/s0006-291x(86)80144-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  Effect of fish oil on levels of R- and S-enantiomers of 5-, 12-, and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa.

Authors:  Andrew P Neilson; Jianwei Ren; Yu H Hong; Ananda Sen; William L Smith; Dean E Brenner; Zora Djuric
Journal:  Nutr Cancer       Date:  2011-12-09       Impact factor: 2.900

2.  12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea.

Authors:  M L Schwartzman; M Balazy; J Masferrer; N G Abraham; J C McGiff; R C Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

Review 3.  12-lipoxygenase: a potential target for novel anti-platelet therapeutics.

Authors:  Jennifer Yeung; Michael Holinstat
Journal:  Cardiovasc Hematol Agents Med Chem       Date:  2011-07-01

Review 4.  Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition.

Authors:  Mariko Nakano; Catherine M Lockhart; Edward J Kelly; Allan E Rettie
Journal:  Drug Metab Rev       Date:  2014-05-26       Impact factor: 4.518

5.  Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation.

Authors:  J Clària; M H Lee; C N Serhan
Journal:  Mol Med       Date:  1996-09       Impact factor: 6.354

Review 6.  Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450.

Authors:  E H Oliw; J Bylund; C Herman
Journal:  Lipids       Date:  1996-10       Impact factor: 1.880

Review 7.  Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.

Authors:  William S Powell; Joshua Rokach
Journal:  Biochim Biophys Acta       Date:  2014-10-29

8.  A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells.

Authors:  M J Holtzman; J Turk; A Pentland
Journal:  J Clin Invest       Date:  1989-11       Impact factor: 14.808

9.  A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.

Authors:  W E Boeglin; R B Kim; A R Brash
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

10.  Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.

Authors:  Michael P Endsley; Nitin Aggarwal; Marilyn A Isbell; Craig E Wheelock; Bruce D Hammock; John R Falck; William B Campbell; Kasem Nithipatikom
Journal:  Int J Cancer       Date:  2007-09-01       Impact factor: 7.396
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