Literature DB >> 31016564

EAST1 toxin: An enigmatic molecule associated with sporadic episodes of diarrhea in humans and animals.

J Daniel Dubreuil1.   

Abstract

EAST1 is produced by a subset of enteroaggregative Escherichia coli strains. This toxin is a 38-amino acid peptide of 4100 Da. It shares 50% homology with the enterotoxic domain of STa and interacts with the same receptor. The mechanism of action of EAST1is proposed to be identical to that of STa eliciting a cGMP increase. EAST1 is associated with diarrheal disease in Man and various animal species including cattle and swine. Nevertheless, as EAST1-positive strains as well as culture supernatants did not provoke unequivocally diarrhea either in animal models or in human volunteers, the role of this toxin in disease is today still debated. This review intent is to examine the role of EAST1 toxin in diarrheal illnesses.

Entities:  

Keywords:  EAST1 toxin; Escherichia coli; diarrhea; enteroaggregative; outbreak

Mesh：

Substances：

Year:  2019        PMID： 31016564     DOI： 10.1007/s12275-019-8651-4

Source DB:  PubMed          Journal:  J Microbiol        ISSN： 1225-8873            Impact factor:   3.422


  6 in total

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Review 6.  Pig vaccination strategies based on enterotoxigenic Escherichia coli toxins.

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Journal:  Braz J Microbiol       Date:  2021-07-10       Impact factor: 2.476
  6 in total

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