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Literature DB >> 3101589

Activity of ciprofloxacin against multiply resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, and group JK corynebacteria.

F R Venezio, W Tatarowicz, C A DiVincenzo, J P O'Keefe.

Abstract

The susceptibilities of multiply resistant clinical isolates of Pseudomonas aeurginosa to ciprofloxacin, norfloxacin, and several beta-lactam and aminoglycoside antibiotics were evaluated. Ciprofloxacin also was compared with methicillin and vancomycin against methicillin-resistant Staphylococcus epidermidis and group JK corynebacteria. Ciprofloxacin exhibited the lowest MICs and MBCs for 90% of the isolates among all of the antibiotics tested against P. aeruginosa. In addition, ciprofloxacin exhibited excellent bactericidal activity against the gram-positive organisms. Clinical trials are necessary to confirm the in vitro results and monitor for emergence of resistance.

Entities: Chemical Species

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Year: 1986 PMID： 3101589 PMCID： PMC180624 DOI： 10.1128/AAC.30.6.940

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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Journal: J Clin Microbiol Date: 1975-01 Impact factor: 5.948

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Authors: M S Simberkoff; J J Rahal
Journal: Antimicrob Agents Chemother Date: 1986-06 Impact factor: 5.191

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Authors: G L Archer; M J Tenenbaum
Journal: Antimicrob Agents Chemother Date: 1980-02 Impact factor: 5.191

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Authors: N X Chin; H C Neu
Journal: Antimicrob Agents Chemother Date: 1984-03 Impact factor: 5.191

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Authors: A L Barry; R N Jones; C Thornsberry; L W Ayers; E H Gerlach; H M Sommers
Journal: Antimicrob Agents Chemother Date: 1984-05 Impact factor: 5.191

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Authors: C Thornsberry; L K McDougal
Journal: J Clin Microbiol Date: 1983-11 Impact factor: 5.948

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Authors: G M Eliopoulos; A Gardella; R C Moellering
Journal: Antimicrob Agents Chemother Date: 1984-03 Impact factor: 5.191

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Authors: R J Fass
Journal: Antimicrob Agents Chemother Date: 1983-10 Impact factor: 5.191

5 in total

Review 1. Coryneform bacteria in infectious diseases: clinical and laboratory aspects.

Authors: M B Coyle; B A Lipsky
Journal: Clin Microbiol Rev Date: 1990-07 Impact factor: 26.132

2. Prevalence of resistance to three fluoroquinolones: assessment of levofloxacin disk test error rates and surrogate predictors of levofloxacin susceptibility. AST Surveillance Group.

Authors: P C Fuchs; A L Barry; S D Brown
Journal: Antimicrob Agents Chemother Date: 1996-07 Impact factor: 5.191