Liu Shuai1,2, Zou Leilei3,4, Wen Wen3,4, Wang Shu3,4, Liu Gangsheng1,5, Li Yinglong1,5, Yang Guoke1,5, Chang Xinrong1,5, Liu Hong3,4, Liao Rongfeng1,2. 1. Anhui Medical University, Hefei, China. 2. Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Anhui, China. 3. Fudan University, Shanghai, China. 4. Department of Ophthalmology, EENT Hospital Affiliate to Fudan University, Shanghai, China. 5. Department of Ophthalmology, Hefei First People's Hospital, Anhui, China.
Abstract
INTRODUCTION: Amblyopia is speculated to be an untreatable disease in the patient, who is beyond the critical period of vision; however, currently, it is treatable in adults. PURPOSE: This study aimed to elucidate whether the treatment is useful in both anisometropic amblyopia and strabismic amblyopia. In addition, the differences were detected between anisometropic amblyopia and strabismic amblyopia after the same perceptual treatment and whether the suppression in anisometropic amblyopia or strabismic amblyopia could be decreased before and after the treatment. METHODS: A binocular perceptual learning was applied for the treatment, the suppression was measured, and the patients were followed up for 2 months after training. Anisometropic amblyopia and strabismic amblyopia groups were subjected to the assessment of stereo, visual acuity, contrast sensitivity, and suppression before and after the training. RESULTS: After 6 weeks of "Diploma Gabor Orientation Coherence" training, in the anisometropic amblyopia group, the outcomes of visual acuity (t = 3.114, p = 0.026) and contrast sensitivity (t = 7.786, p = 0.001) were increased significantly. While in the strabismic amblyopia group, the outcomes of stereo (t = 2.987, p = 0.040) and contrast sensitivity (t = 3.638, p = 0.022) were increased significantly. CONCLUSION: After Diploma Gabor Orientation Coherence training in the same frequency and in the same duration, the anisometropic amblyopia group got an improvement in visual acuity, but the strabismic amblyopia group got an improvement in stereo. As there are evidences to show that anisometropic amblyopia and strabismic amblyopia were injured in different pathways, we think the diverse results might come from the different pathway injury in anisometropic amblyopia and strabismic amblyopia.
INTRODUCTION: Amblyopia is speculated to be an untreatable disease in the patient, who is beyond the critical period of vision; however, currently, it is treatable in adults. PURPOSE: This study aimed to elucidate whether the treatment is useful in both anisometropic amblyopia and strabismic amblyopia. In addition, the differences were detected between anisometropic amblyopia and strabismic amblyopia after the same perceptual treatment and whether the suppression in anisometropic amblyopia or strabismic amblyopia could be decreased before and after the treatment. METHODS: A binocular perceptual learning was applied for the treatment, the suppression was measured, and the patients were followed up for 2 months after training. Anisometropic amblyopia and strabismic amblyopia groups were subjected to the assessment of stereo, visual acuity, contrast sensitivity, and suppression before and after the training. RESULTS: After 6 weeks of "Diploma Gabor Orientation Coherence" training, in the anisometropic amblyopia group, the outcomes of visual acuity (t = 3.114, p = 0.026) and contrast sensitivity (t = 7.786, p = 0.001) were increased significantly. While in the strabismic amblyopia group, the outcomes of stereo (t = 2.987, p = 0.040) and contrast sensitivity (t = 3.638, p = 0.022) were increased significantly. CONCLUSION: After Diploma Gabor Orientation Coherence training in the same frequency and in the same duration, the anisometropic amblyopia group got an improvement in visual acuity, but the strabismic amblyopia group got an improvement in stereo. As there are evidences to show that anisometropic amblyopia and strabismic amblyopia were injured in different pathways, we think the diverse results might come from the different pathway injury in anisometropic amblyopia and strabismic amblyopia.
Authors: Carlos Javier Hernández-Rodríguez; Hideki Fukumitsu; Pedro Ruiz-Fortes; Roberto Soto-Negro; María Merino-Suárez; David P Piñero Journal: Vision (Basel) Date: 2021-03-23