| Literature DB >> 31012734 |
Jie Qiu1,2,3, Chun-Mao Yuan1,2,3, Min Wen1,3, Ya-Nan Li1,2,3, Juan Chen1,2,3, Jun-You Jian1,2,3, Lie-Jun Huang1,2,3, Wei Gu1,2,3, Yan-Mei Li1,2,3, Xiao-Jiang Hao1,2,3,4.
Abstract
A series of novel parthenolide-thiazolidinedione hybrids have been synthesized via a click chemistry-mediated coupling between parthenolide and thiazolidinedione, and evaluated for their cytotoxic activities. The results indicated that all the hybrids showed moderate cytotoxic effects on human cancer cell lines, including human erythroleukemia cell line (HEL), prostate (PC3), and breast (MDA-MB-231) by MTT assay. In particular, compound VI-6 exhibited the best cytotoxic activities against the MDA-MB-231 cells with IC50 value of 2.07 µM, which was about eight times more active than that of the original compound (PTL). These interesting results might be used to develop novel lead scaffolds for potential anticancer agents.Entities:
Keywords: Parthenolide–thiazolidinedione hybrids; click chemistry; cytotoxic activities
Year: 2019 PMID： 31012734 DOI： 10.1080/10286020.2019.1597055
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569