Literature DB >> 31012503

Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings, and Future Avenues of Research.

Britt I Drögemöller1,2, Galen E B Wright2,3, Cody Lo2,4, Tan Le1, Beth Brooks5, Amit P Bhavsar6, Shahrad R Rassekh2,3, Colin J D Ross1,2, Bruce C Carleton2,3.   

Abstract

Cisplatin is a highly effective chemotherapeutic. Unfortunately, its use is limited by cisplatin-induced ototoxicity (CIO). Substantial research has been performed to uncover the genetic variants associated with CIO; however, there has been a lack of consistency in the results that have been reported. This paper aims to provide an overview of the current state of CIO genomics research, delving into the shortcomings of past research, and providing recommendations for future avenues of study.
© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2019        PMID： 31012503     DOI： 10.1002/cpt.1483

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  6 in total

1.  Pharmacogenetics: Chasing Perfection.

Authors:  Andrea Gaedigk
Journal:  Clin Pharmacol Ther       Date:  2019-08       Impact factor: 6.875

2.  Dioscin Alleviates Cisplatin-Induced Mucositis in Rats by Modulating Gut Microbiota, Enhancing Intestinal Barrier Function and Attenuating TLR4/NF-κB Signaling Cascade.

Authors:  Shengzi Jin; Tongxu Guan; Shuang Wang; Mengxin Hu; Xingyao Liu; Siqi Huang; Yun Liu
Journal:  Int J Mol Sci       Date:  2022-04-17       Impact factor: 6.208

Review 3.  Current Strategies to Combat Cisplatin-Induced Ototoxicity.

Authors:  Dehong Yu; Jiayi Gu; Yuming Chen; Wen Kang; Xueling Wang; Hao Wu
Journal:  Front Pharmacol       Date:  2020-07-03       Impact factor: 5.810

4.  Insight into the current practice of ototoxicity monitoring during cisplatin therapy.

Authors:  N M Santucci; B Garber; R Ivory; M A Kuhn; M Stephen; D Aizenberg
Journal:  J Otolaryngol Head Neck Surg       Date:  2021-03-25

5.  Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in non-small cell lung cancer.

Authors:  Chenxue Mao; Juan Chen; Ting Zou; Yuankang Zhou; Junyan Liu; Xi Li; Xiangping Li; Min Li; Pinhua Pan; Wei Zhuo; Yang Gao; Shuo Hu; Desheng Xiao; Lin Wu; Zhan Wang; Heng Xu; Wen Yang; Yingjie Xu; Haihua Xiao; Kazuhiko Hanada; Wei Zhang; Honghao Zhou; Jiye Yin; Zhaoqian Liu
Journal:  Acta Pharm Sin B       Date:  2021-10-16       Impact factor: 14.903

Review 6.  The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition.

Authors:  Zulfan Zazuli; Naut J C B Duin; Katja Jansen; Susanne J H Vijverberg; Anke H Maitland-van der Zee; Rosalinde Masereeuw
Journal:  Int J Mol Sci       Date:  2020-09-10       Impact factor: 5.923
  6 in total

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