Intrinsic connectivity identifies the sensory-motor network as a main cross-network between remitted late-life depression- and amnestic mild cognitive impairment-targeted networks.

Remitted late-life depression (rLLD) and amnestic mild cognitive impairment (aMCI) are both associated with a high risk of developing Alzheimer's disease (AD). Neurodegeneration is considered to spread within pre-existing networks. To investigate whether, in the healthy brain, there was a pre-existing cross-network between the intrinsic networks that are vulnerable to rLLD and aMCI. We performed functional connectivity analyses based on brain areas with the greatest brain neuronal activity differences in 55 rLLD, 87 aMCI, and 114 healthy controls. Intrinsic networks that were differentially vulnerable to rLLD and aMCI converged onto the sensory-motor network (SMN) in the healthy brain. These regions in the SMN within the aMCI- and rLLD-vulnerable networks played different roles in the cognitive functions. This study identifies the SMN as a cross-network between rLLD- and aMCI-vulnerable networks. The common susceptibility of these diseases to AD is likely due to the breakdown of the cross-network. The results further suggest that interventions targeting the amelioration of sensory-motor deficits in the early course of disease in individuals with AD risk may enhance patient function as AD pathology progresses.