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Literature DB >> 31010530

Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight.

Natalie Garzorz-Stark¹, Kilian Eyerich².

Abstract

Psoriasis is a T helper type 17-mediated immune disease. Initial triggers that lead to T helper type 17 production and inflammatory cell recruitment into skin are being delineated. Autoantigens that stimulate T helper type 17 cells are also being identified. A new and important piece of the puzzle indicates that keratinocytes not only amplify inflammation, but that they are essential for a full-blown IL-17-mediated psoriatic phenotype in mice.

Entities: Disease Gene Species

Mesh：

Substances：
Interleukin-17
Imiquimod

Year: 2019 PMID： 31010530 DOI： 10.1016/j.jid.2019.01.026

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

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Cited

10 in total

1. Investigation on the Mechanism of Qubi Formula in Treating Psoriasis Based on Network Pharmacology.

Authors: Lin Zhou; Lingyun Zhang; Disheng Tao
Journal: Evid Based Complement Alternat Med Date: 2020-06-21 Impact factor: 2.629

2. Anoctamin1 Induces Hyperproliferation of HaCaT Keratinocytes and Triggers Imiquimod-Induced Psoriasis-Like Skin Injury in Mice.

Authors: Mi Ran Choi; Hae Dong Kim; Sinyoung Cho; Seong Ho Jeon; Dong Hyun Kim; Jungwon Wee; Young Duk Yang
Journal: Int J Mol Sci Date: 2021-07-01 Impact factor: 5.923

3. Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment.

Authors: Immo Prinz; Inga Sandrock; Ulrich Mrowietz
Journal: J Exp Med Date: 2020-01-06 Impact factor: 14.307

Review 4. IL-17A in Psoriasis and Beyond: Cardiovascular and Metabolic Implications.

Authors: Esther von Stebut; Wolf-Henning Boehncke; Kamran Ghoreschi; Tommaso Gori; Ziya Kaya; Diamant Thaci; Andreas Schäffler
Journal: Front Immunol Date: 2020-01-15 Impact factor: 7.561

5. Acitretin-Conjugated Dextran Nanoparticles Ameliorate Psoriasis-like Skin Disease at Low Dosages.

Authors: Jiajia Lan; Yuce Li; Jingjing Wen; Yu Chen; Jing Yang; Liang Zhao; Yuting Xia; Hongyao Du; Juan Tao; Yan Li; Jintao Zhu
Journal: Front Bioeng Biotechnol Date: 2022-01-07

6. Dihydroartemisinin targets fibroblast growth factor receptor 1 (FGFR1) to inhibit interleukin 17A (IL-17A)-induced hyperproliferation and inflammation of keratinocytes.

Authors: Baojiang Chen; Chen Li; Guizhen Chang; Huan Wang
Journal: Bioengineered Date: 2022-01 Impact factor: 3.269

Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight.

1. Investigation on the Mechanism of Qubi Formula in Treating Psoriasis Based on Network Pharmacology.

2. Anoctamin1 Induces Hyperproliferation of HaCaT Keratinocytes and Triggers Imiquimod-Induced Psoriasis-Like Skin Injury in Mice.

3. Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment.

Review 4. IL-17A in Psoriasis and Beyond: Cardiovascular and Metabolic Implications.

5. Acitretin-Conjugated Dextran Nanoparticles Ameliorate Psoriasis-like Skin Disease at Low Dosages.

6. Dihydroartemisinin targets fibroblast growth factor receptor 1 (FGFR1) to inhibit interleukin 17A (IL-17A)-induced hyperproliferation and inflammation of keratinocytes.

7. Transcriptome wide analysis of long non-coding RNA-associated ceRNA regulatory circuits in psoriasis.

8. Genital Psoriasis and Associated Factors of Sexual Avoidance - A People-centered Cross-sectional Study in Germany.

9. miR-183-3p suppresses proliferation and migration of keratinocyte in psoriasis by inhibiting GAB1.

Review 10. Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis.