| Literature DB >> 31008606 |
Birthe Sandargo1,2, Maira Michehl1,2, Dimas Praditya3,4, Eike Steinmann3,5, Marc Stadler1,2, Frank Surup1,2.
Abstract
Rhodatin (1), a meroterpenoid featuring a unique pentacyclic scaffold with both spiro and spiroketal centers, and five unusual acorane-type sesquiterpenoids, named rhodocoranes A-E (2-6, respectively), are the first natural products isolated from the basidiomycete Rhodotus palmatus. Their structures were elucidated by two-dimensional NMR experiments and HRESIMS, while the absolute configuration of the substance family was determined by Mosher's method utilizing 2. Rhodatin strongly inhibited hepatitis C virus, whereas 4 displayed cytotoxicity and selective antifungal activity.Entities:
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Year: 2019 PMID： 31008606 DOI： 10.1021/acs.orglett.9b01017
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005