Megan L Noonan1, Kenneth E White1. 1. Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Abstract
PURPOSE OF REVIEW: The phosphaturic hormone FGF23 is produced primarily in osteoblasts/osteocytes and is known to respond to increases in serum phosphate and 1,25(OH)2 vitamin D (1,25D). Novel regulators of FGF23 were recently identified, and may help explain the pathophysiologies of several diseases. This review will focus on recent studies examining the synthesis and actions of FGF23. RECENT FINDINGS: The synthesis of FGF23 in response to 1,25D is similar to other steroid hormone targets, but the cellular responses to phosphate remain largely unknown. The activity of intracellular processing genes control FGF23 glycosylation and phosphorylation, providing critical functions in determining the serum levels of bioactive FGF23. The actions of FGF23 largely occur through its co-receptor αKlotho (KL) under normal circumstances, but FGF23 has KL-independent activity during situations of high concentrations. SUMMARY: Recent work regarding FGF23 synthesis and bioactivity, as well as considerations for diseases of altered phosphate balance will be reviewed.
PURPOSE OF REVIEW: The phosphaturic hormone FGF23 is produced primarily in osteoblasts/osteocytes and is known to respond to increases in serum phosphate and 1,25(OH)2 vitamin D (1,25D). Novel regulators of FGF23 were recently identified, and may help explain the pathophysiologies of several diseases. This review will focus on recent studies examining the synthesis and actions of FGF23. RECENT FINDINGS: The synthesis of FGF23 in response to 1,25D is similar to other steroid hormone targets, but the cellular responses to phosphate remain largely unknown. The activity of intracellular processing genes control FGF23 glycosylation and phosphorylation, providing critical functions in determining the serum levels of bioactive FGF23. The actions of FGF23 largely occur through its co-receptor αKlotho (KL) under normal circumstances, but FGF23 has KL-independent activity during situations of high concentrations. SUMMARY: Recent work regarding FGF23 synthesis and bioactivity, as well as considerations for diseases of altered phosphate balance will be reviewed.
Authors: Farzana Perwad; Nasreen Azam; Martin Y H Zhang; Takeyoshi Yamashita; Harriet S Tenenhouse; Anthony A Portale Journal: Endocrinology Date: 2005-08-25 Impact factor: 4.736
Authors: Olga I Kolek; Eric R Hines; Marci D Jones; Loren K LeSueur; Maciej A Lipko; Pawel R Kiela; James F Collins; Mark R Haussler; Fayez K Ghishan Journal: Am J Physiol Gastrointest Liver Physiol Date: 2005-07-14 Impact factor: 4.052
Authors: T Shimada; S Mizutani; T Muto; T Yoneya; R Hino; S Takeda; Y Takeuchi; T Fujita; S Fukumoto; T Yamashita Journal: Proc Natl Acad Sci U S A Date: 2001-05-08 Impact factor: 11.205
Authors: Yohana Camila Garay; Romina Beatriz Cejas; Virginia Lorenz; Natacha Zlocowski; Pedro Parodi; Franco Alejandro Ferrero; Genaro Angeloni; Valentina Alfonso García; Victor German Sendra; Ricardo Dante Lardone; Fernando José Irazoqui Journal: J Mol Med (Berl) Date: 2022-09-02 Impact factor: 5.606
Authors: Matthew Prideaux; Christian S Wright; Megan L Noonan; Xin Yi; Erica L Clinkenbeard; Elsa Mevel; Jonathan A Wheeler; Sharon Byers; Asiri R Wijenayaka; Stan Gronthos; Uma Sankar; Kenneth E White; Gerald J Atkins; William R Thompson Journal: Sci Rep Date: 2021-11-19 Impact factor: 4.379
Authors: Pu Ni; Erica L Clinkenbeard; Megan L Noonan; Joseph M Richardville; Jeanette McClintick; Takashi Hato; Danielle Janosevic; Ying-Hua Cheng; Tarek M El-Achkar; Michael T Eadon; Pierre C Dagher; Kenneth E White Journal: Kidney Int Date: 2020-11-04 Impact factor: 10.612