Laura Sportouch1, Jennifer Cautela1, Noémie Resseguier2, Johan Pinto1, Chloé Ammar1, Mélanie Gaubert1, Jérémie Barraud1, Michael Peyrol1, Marc Laine1, Laurent Bonello3, Serge Yvorra4, Franck Paganelli3, Franck Thuny5. 1. Heart Failure and Valvular Heart Disease Unit, Mediterranean University Cardio-Oncology (MEDI-CO) Centre, Department of Cardiology, Aix-Marseille University, hôpital Nord, AP-HM, chemin des Bourrely, 13015 Marseille, France; Inserm 1263, INRA, centre de recherche cardiovasculaire et nutrition (C2VN), Aix-Marseille University, 13385 Marseille, France. 2. Research Unit EA 3279, Department of Public Health, Aix-Marseille University, 13385 Marseille, France. 3. Heart Failure and Valvular Heart Disease Unit, Mediterranean University Cardio-Oncology (MEDI-CO) Centre, Department of Cardiology, Aix-Marseille University, hôpital Nord, AP-HM, chemin des Bourrely, 13015 Marseille, France; Inserm 1263, INRA, centre de recherche cardiovasculaire et nutrition (C2VN), Aix-Marseille University, 13385 Marseille, France; Inserm, UMRS 1076, Aix-Marseille University, 13385 Marseille, France. 4. Department of Cardiology, Martigues Hospital, 13500 Martigues, France. 5. Heart Failure and Valvular Heart Disease Unit, Mediterranean University Cardio-Oncology (MEDI-CO) Centre, Department of Cardiology, Aix-Marseille University, hôpital Nord, AP-HM, chemin des Bourrely, 13015 Marseille, France; Inserm 1263, INRA, centre de recherche cardiovasculaire et nutrition (C2VN), Aix-Marseille University, 13385 Marseille, France. Electronic address: franck.thuny@gmail.com.
Abstract
BACKGROUND: Iron deficiency (ID) is common in heart failure (HF), and is associated with unfavourable clinical outcomes. Although it is recommended to screen for ID in HF, there is no clear consensus on the optimal timing of its assessment. AIM: To analyse changes in iron status during a short-term follow-up in patients admitted for acute HF. METHODS: Iron status (serum ferritin concentration and transferrin saturation) was determined in 110 consecutive patients (median age: 81 years) admitted to a referral centre for acute HF, at three timepoints (admission, discharge and 1 month after discharge). ID was defined according to the guidelines. RESULTS: The prevalence rates of ID at admission, discharge and 1 month were, respectively, 75% (95% confidence interval [CI] 67-83%), 61% (95% CI: 52-70%), and 70% (95% CI: 61-79%) (P=0.008). Changes in prevalence were significant between admission and discharge (P=0.0018). Despite a similar ID prevalence at admission and 1 month (P=0.34), iron status changed in 25% of patients. Between admission and discharge, variation in C-reactive protein correlated significantly with that of ferritin (ρ=0.30; P=0.001). Advanced age, anaemia, low ferritin concentration and low creatinine clearance were associated with the persistence of ID from admission to 1 month. CONCLUSIONS: Iron status is dynamic in patients admitted for acute HF. Although ID was as frequent at admission as at 1 month after discharge, iron status varied in 25% of patients.
BACKGROUND:Iron deficiency (ID) is common in heart failure (HF), and is associated with unfavourable clinical outcomes. Although it is recommended to screen for ID in HF, there is no clear consensus on the optimal timing of its assessment. AIM: To analyse changes in iron status during a short-term follow-up in patients admitted for acute HF. METHODS:Iron status (serum ferritin concentration and transferrin saturation) was determined in 110 consecutive patients (median age: 81 years) admitted to a referral centre for acute HF, at three timepoints (admission, discharge and 1 month after discharge). ID was defined according to the guidelines. RESULTS: The prevalence rates of ID at admission, discharge and 1 month were, respectively, 75% (95% confidence interval [CI] 67-83%), 61% (95% CI: 52-70%), and 70% (95% CI: 61-79%) (P=0.008). Changes in prevalence were significant between admission and discharge (P=0.0018). Despite a similar ID prevalence at admission and 1 month (P=0.34), iron status changed in 25% of patients. Between admission and discharge, variation in C-reactive protein correlated significantly with that of ferritin (ρ=0.30; P=0.001). Advanced age, anaemia, low ferritin concentration and low creatinine clearance were associated with the persistence of ID from admission to 1 month. CONCLUSIONS:Iron status is dynamic in patients admitted for acute HF. Although ID was as frequent at admission as at 1 month after discharge, iron status varied in 25% of patients.
Authors: Dirk H van Dalen; Johannes A Kragten; Mireille E Emans; Clara E E van Ofwegen-Hanekamp; Claudia C R Klaarwater; Mireille H A Spanjers; Rémond Hendrick; Cees Th B M van Deursen; Hans-Peter Brunner-La Rocca Journal: ESC Heart Fail Date: 2021-12-04
Authors: Theo Pezel; Etienne Audureau; Jacques Mansourati; Guillaume Baudry; Ahmed Ben Driss; Florence Durup; Marie Fertin; Christian Godreuil; Julien Jeanneteau; Martin Kloeckner; François Koukoui; Lamia Kesri-Tartière; Thierry Laperche; François Roubille; Alain Cohen-Solal; Thibaud Damy Journal: ESC Heart Fail Date: 2021-02-22