Fabrizio Vecchio1, Pietro Caliandro2, Giuseppe Reale3, Francesca Miraglia4, Francesca Piludu5, Gianvito Masi3, Chiara Iacovelli6, Chiara Simbolotti2, Luca Padua7, Edoardo Leone5, Francesca Alù1, Cesare Colosimo5, Paolo Maria Rossini8. 1. Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Rome, Italy. 2. Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 3. Institute of Neurology, Area of Neuroscience, Catholic University of The Sacred Heart, Rome, Italy. 4. Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: francesca.miraglia@sanraffaele.it. 5. Department of radiologic sciences, Catholic University, Fondazione Policlincio Universitario A. Gemelli, Rome, Italy. 6. IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy. 7. Unità operativa di neuroriabilitazione ad alta intensità, Fondazione Policlinico Universitario A. Gemelli. IRCCS, Roma. 8. Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Neurology, Area of Neuroscience, Catholic University of The Sacred Heart, Rome, Italy.
Abstract
OBJECTIVE: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms. METHODS: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. RESULTS: The delta network remodeling was similar in cerebellar and middle cerebral artery strokes, with a reduction of small-worldness. Beta 2 and gamma small-worldness, in the right hemisphere of patients with cerebellar stroke, increase respect to healthy subjects, while alpha 2 small-worldness increases only among patients with a middle cerebral artery stroke. CONCLUSIONS: The network remodeling characteristics are independent on the size of the ischemic lesion. In the early post-acute stages cerebellar stroke differs from the middle cerebral artery one because it does not cause alpha 2 network remodeling while it determines a high frequency network reorganization in beta 2 and gamma bands with an increase of small-worldness characteristics. SIGNIFICANCE: These findings demonstrate changes in the balance of local segregation and global integration induced by cerebellar acute stroke in high EEG frequency bands. They need to be integrated with appropriate follow-up to explore whether further network changes are attained during post-stroke outcome stabilization.
OBJECTIVE: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms. METHODS: Graph parameters of 41 consecutive strokepatients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of strokepatients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. RESULTS: The delta network remodeling was similar in cerebellar and middle cerebral artery strokes, with a reduction of small-worldness. Beta 2 and gamma small-worldness, in the right hemisphere of patients with cerebellar stroke, increase respect to healthy subjects, while alpha 2 small-worldness increases only among patients with a middle cerebral artery stroke. CONCLUSIONS: The network remodeling characteristics are independent on the size of the ischemic lesion. In the early post-acute stages cerebellar stroke differs from the middle cerebral artery one because it does not cause alpha 2 network remodeling while it determines a high frequency network reorganization in beta 2 and gamma bands with an increase of small-worldness characteristics. SIGNIFICANCE: These findings demonstrate changes in the balance of local segregation and global integration induced by cerebellar acute stroke in high EEG frequency bands. They need to be integrated with appropriate follow-up to explore whether further network changes are attained during post-stroke outcome stabilization.
Authors: Sander Lindeman; Sungho Hong; Lieke Kros; Jorge F Mejias; Vincenzo Romano; Robert Oostenveld; Mario Negrello; Laurens W J Bosman; Chris I De Zeeuw Journal: Proc Natl Acad Sci U S A Date: 2021-01-12 Impact factor: 11.205