Literature DB >> 3100460

Effects of DL-alpha-difluoromethylornithine on the growth and metastasis of B16 melanoma in vivo.

S Kubota, N Ohsawa, F Takaku.   

Abstract

The effects of DL-alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ornithine decarboxylase, on the growth of experimental mouse B16-F10 melanoma cells were investigated. DFMO (3%) in drinking water was administered to B16-F10 melanoma-bearing mice. At 24 days, B16-F10 melanomas in DFMO-fed mice weighed 75% less than those in control mice (p less than 0.001). DFMO reduced putrescine and spermidine levels in B16-F10 melanoma by 98% and 84%, respectively, and prolonged the mean survival time from 25.9 +/- 1.2 to 35.7 +/- 2.2 days (p less than 0.001). The effects of DFMO on experimental metastasis were also investigated. DFMO treatment resulted in a significant decrease in pulmonary metastasis induced by i.v. injection of B16-F10 melanoma cells.

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Year:  1987        PMID： 3100460     DOI： 10.1002/ijc.2910390220

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  9 in total

1.  alpha-Difluoromethylornithine inhibits liver metastasis produced by intrasplenic injection of human tumor cells into nude mice.

Authors:  K A Zirvi; K S Dasmahapatra; U Atabek; M A Lyons
Journal:  Clin Exp Metastasis       Date:  1989 Nov-Dec       Impact factor: 5.150

2.  Prevention of metastasis of intraocular melanoma in mice treated with difluoromethylornithine.

Authors:  G Sanborn; J Niederkorn; J Kan-Mitchell; D Albert
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1992       Impact factor: 3.117

3.  Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.

Authors:  M Klouche; H Kirchner; F Hölzel
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

Review 4.  Chemoprevention of melanoma.

Authors:  Subbarao V Madhunapantula; Gavin P Robertson
Journal:  Adv Pharmacol       Date:  2012

Review 5.  The mechanisms by which polyamines accelerate tumor spread.

Authors:  Kuniyasu Soda
Journal:  J Exp Clin Cancer Res       Date:  2011-10-11

6.  Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.

Authors:  Y Ashida; A Ueno; Y Miwa; K Miyoshi; H Inoue
Journal:  Jpn J Cancer Res       Date:  1998-01

7.  DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.

Authors:  Dana-Lynn T Koomoa; Dirk Geerts; Ingo Lange; Jan Koster; Anthony E Pegg; David J Feith; André S Bachmann
Journal:  Int J Oncol       Date:  2013-02-21       Impact factor: 5.650

8.  Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade.

Authors:  Parker Dryja; Carrie Fisher; Patrick M Woster; Eric Bartee
Journal:  J Immunother       Date:  2021-10-01       Impact factor: 4.912

9.  Polyamine depletion induces G1 and S phase arrest in human retinoblastoma Y79 cells.

Authors:  Akiko Ueda; Makoto Araie; Shunichiro Kubota
Journal:  Cancer Cell Int       Date:  2008-01-21       Impact factor: 5.722
  9 in total

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