Literature DB >> 31004352

Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.

Alexandra Zakharenko1, Nadezhda Dyrkheeva1, Olga Lavrik1,2.   

Abstract

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that catalyzes the hydrolysis of the phosphodiester bond in the DNA-topoisomerase 1 (Top1) covalent complex and repairs some other 3'-end DNA adducts. Currently, Tdp1 functions as an important target in cancer drug design owing to its ability to break down various DNA adducts induced by chemotherapeutics. Tdp1 inhibitors may sensitize tumor cells to the action of Top1 poisons, thereby potentiating their effects. This mini-review summarizes findings from studies reporting the combined inhibition of Top1 and Tdp1. Two different approaches have been considered for developing such drug precursors.
© 2019 Wiley Periodicals, Inc.

Entities:  

Keywords:  Tdp1 inhibitors; Top1 poisons; topoisomerase 1; tyrosyl-DNA phosphodiesterase 1 (Tdp1); tyrosyl-DNA phosphodiesterase 2

Mesh：

Substances：

Year:  2019        PMID： 31004352     DOI： 10.1002/med.21587

Source DB:  PubMed          Journal:  Med Res Rev        ISSN： 0198-6325            Impact factor:   12.944


  9 in total

1.  In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.

Authors:  Nadezhda S Dyrkheeva; Irina A Chernyshova; Georgy A Ivanov; Yuri B Porozov; Anastasia A Zenchenko; Vladimir E Oslovsky; Alexandra L Zakharenko; Darina I Nasyrova; Galina N Likhatskaya; Sergey N Mikhailov; Olga I Lavrik; Mikhail S Drenichev
Journal:  Molecules       Date:  2022-04-09       Impact factor: 4.927

2.  The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo.

Authors:  V P Nikolin; N A Popova; V I Kaledin; O A Luzina; A L Zakharenko; N F Salakhutdinov; O I Lavrik
Journal:  Clin Exp Metastasis       Date:  2021-08-09       Impact factor: 5.150

3.  Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I.

Authors:  Lauren R H Krumpe; Brice A P Wilson; Christophe Marchand; Suthananda N Sunassee; Alun Bermingham; Wenjie Wang; Edmund Price; Tad Guszczynski; James A Kelley; Kirk R Gustafson; Yves Pommier; K Johan Rosengren; Christina I Schroeder; Barry R O'Keefe
Journal:  J Am Chem Soc       Date:  2020-12-02       Impact factor: 15.419

4.  Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.

Authors:  Tatyana M Khomenko; Alexandra L Zakharenko; Arina A Chepanova; Ekaterina S Ilina; Olga D Zakharova; Vasily I Kaledin; Valeriy P Nikolin; Nelly A Popova; Dina V Korchagina; Jóhannes Reynisson; Raina Chand; Daniel M Ayine-Tora; Jinal Patel; Ivanhoe K H Leung; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Int J Mol Sci       Date:  2019-12-23       Impact factor: 5.923

5.  Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides.

Authors:  Alexandra L Zakharenko; Mikhail S Drenichev; Nadezhda S Dyrkheeva; Georgy A Ivanov; Vladimir E Oslovsky; Ekaterina S Ilina; Irina A Chernyshova; Olga I Lavrik; Sergey N Mikhailov
Journal:  Molecules       Date:  2020-08-13       Impact factor: 4.411

6.  Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site.

Authors:  Natalia A Lebedeva; Nadejda I Rechkunova; Anton V Endutkin; Olga I Lavrik
Journal:  Front Cell Dev Biol       Date:  2021-01-11

7.  New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.

Authors:  Nadezhda S Dyrkheeva; Aleksandr S Filimonov; Olga A Luzina; Kristina A Orlova; Irina A Chernyshova; Tatyana E Kornienko; Anastasia A Malakhova; Sergey P Medvedev; Alexandra L Zakharenko; Ekaterina S Ilina; Rashid O Anarbaev; Konstantin N Naumenko; Kristina V Klabenkova; Ekaterina A Burakova; Dmitry A Stetsenko; Suren M Zakian; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Int J Mol Sci       Date:  2021-10-20       Impact factor: 5.923

8.  Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1.

Authors:  Irina V Il'ina; Nadezhda S Dyrkheeva; Alexandra L Zakharenko; Alexander Yu Sidorenko; Nikolay S Li-Zhulanov; Dina V Korchagina; Raina Chand; Daniel M Ayine-Tora; Arina A Chepanova; Olga D Zakharova; Ekaterina S Ilina; Jóhannes Reynisson; Anastasia A Malakhova; Sergey P Medvedev; Suren M Zakian; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Molecules       Date:  2020-07-31       Impact factor: 4.411

9.  A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.

Authors:  Ann-Katrine Jakobsen; Josephine Geertsen Keller; María Gonzalez; Endika Martin-Encinas; Francisco Palacios; Concepcion Alonso; Birgitta Ruth Knudsen; Magnus Stougaard
Journal:  Sensors (Basel)       Date:  2021-07-15       Impact factor: 3.576
  9 in total

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