Literature DB >> 3100406

Hydroxychavicol: a new phenolic antimutagen from betel leaf.

A J Amonkar, M Nagabhushan, A V D'Souza, S V Bhide.   

Abstract

The phenolic compounds eugenol and hydroxychavicol were separated from betel leaf extract using C18 phase bonded Hiflosil silica gel. The structures of the two compounds were confirmed by nuclear magnetic resonance data. Neither eugenol nor hydroxychavicol was mutagenic when tested in various strains of Salmonella typhimurium with or without metabolic activation. Both compounds exhibited dose-dependent suppression of dimethylbenzanthracene-induced mutagenesis in S. typhimurium strain TA98 with metabolic activation. Hydroxychavicol was more potent than eugenol in this respect.

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Year:  1986        PMID： 3100406     DOI： 10.1016/0278-6915(86)90065-7

Source DB:  PubMed          Journal:  Food Chem Toxicol        ISSN： 0278-6915            Impact factor:   6.023


  11 in total

1.  Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis.

Authors:  Sushma Reddy Gundala; Chunhua Yang; Rao Mukkavilli; Rutugandha Paranjpe; Meera Brahmbhatt; Vaishali Pannu; Alice Cheng; Michelle D Reid; Ritu Aneja
Journal:  Toxicol Appl Pharmacol       Date:  2014-07-23       Impact factor: 4.219

2.  Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol: roles of glutathione and reactive oxygen species.

Authors:  M C Chang; B J Uang; H L Wu; J J Lee; L J Hahn; J H Jeng
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

3.  Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: an in vitro and in vivo assessment.

Authors:  Savita Verma; Manju Lata Gupta; Ajaswrata Dutta; Sanghmitra Sankhwar; Sandeep Kumar Shukla; Swaran J S Flora
Journal:  Oxid Med Cell Longev       Date:  2010 Jan-Feb       Impact factor: 6.543

4.  Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization.

Authors:  M C Chang; B J Uang; C Y Tsai; H L Wu; B R Lin; C S Lee; Y J Chen; C H Chang; Y L Tsai; C J Kao; J H Jeng
Journal:  Br J Pharmacol       Date:  2007-07-16       Impact factor: 8.739

5.  Catechin as an antimutagen: its mode of action.

Authors:  M Nagabhushan; G B Maru; A J Amonkar; U J Nair; U Santhanam; N Ammigan; A V D'Souza; S V Bhide
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

6.  Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products.

Authors:  S V Bhide; M A Azuine; M Lahiri; N T Telang
Journal:  Breast Cancer Res Treat       Date:  1994       Impact factor: 4.872

7.  Arecanut as an emerging etiology of oral cancers in India.

Authors:  Gunjan Shah; Pankaj Chaturvedi; Sagar Vaishampayan
Journal:  Indian J Med Paediatr Oncol       Date:  2012-04

8.  Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats.

Authors:  Somaya Zakaria Mansour; Hanan El-Kabany
Journal:  Chin Med       Date:  2009-01-30       Impact factor: 5.455

9.  Prevalence and determinants of biochemical dysfunction of the liver in Atayal Aboriginal community of Taiwan: is betel nut chewing a risk factor?

Authors:  Ching-Feng Lin; Tun-Jen Shiau; Ying-Chin Ko; Ping-Ho Chen; Jung-Der Wang
Journal:  BMC Gastroenterol       Date:  2008-04-27       Impact factor: 3.067

10.  Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway.

Authors:  Avik Acharya Chowdhury; Jaydeep Chaudhuri; Nabendu Biswas; Anirban Manna; Saurav Chatterjee; Sanjit K Mahato; Utpal Chaudhuri; Parasuraman Jaisankar; Santu Bandyopadhyay
Journal:  PLoS One       Date:  2013-09-09       Impact factor: 3.240
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