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Literature DB >> 31003921

Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.

Pattara Wiromrat¹, Petter Bjornstad², Carlos Roncal³, Melanie Cree-Green⁴, Amy Baumgartner¹, Gregory Coe¹, Yesenia Garcia Reyes¹, Michal Schäfer⁵, Uyen Truong⁵, Laura Pyle¹, Richard J Johnson³, Kristen J Nadeau⁶.

Abstract

Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potential as a CVD biomarker in T1D.

Entities: Chemical Disease Gene Species

Keywords: Adolescents; Aortic stiffness; Ascending aortic pulse wave velocity; Relative area change; Serum uromodulin; Type 1 diabetes

Year: 2019 PMID： 31003921 PMCID： PMC6908304 DOI： 10.1016/j.jdiacomp.2019.03.001

Source DB: PubMed Journal: J Diabetes Complications ISSN： 1056-8727 Impact factor: 2.852

19 in total

Review 1. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis.

Authors: Charalambos Vlachopoulos; Konstantinos Aznaouridis; Christodoulos Stefanadis
Journal: J Am Coll Cardiol Date: 2010-03-30 Impact factor: 24.094

2. Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients.

Authors: Andreas Leiherer; Axel Muendlein; Christoph H Saely; Janine Ebner; Eva M Brandtner; Peter Fraunberger; Heinz Drexel
Journal: Int J Cardiol Date: 2016-12-29 Impact factor: 4.164

3. Tamm-Horsfall-Protein excretion as a marker of ascending limb transport indicates early renal tubular damage in diabetes mellitus type I.

Authors: L B Zimmerhackl; S Pfleiderer; R Kinne; F Manz; G Schuler; M Brandis
Journal: J Diabet Complications Date: 1991 Apr-Sep

Review 4. Type 1 diabetes and coronary artery disease.

Authors: Trevor J Orchard; Tina Costacou; Adam Kretowski; Richard W Nesto
Journal: Diabetes Care Date: 2006-11 Impact factor: 19.112

5. Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.

Authors: Michael A McCulloch; Nelly Mauras; Jose A Canas; Jobayer Hossain; Kaitlin M Sikes; Ligeia C Damaso; Alban Redheuil; Judith L Ross; Samuel S Gidding
Journal: Pediatr Diabetes Date: 2014-12-18 Impact factor: 4.866

Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.

Review 1. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis.

2. Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients.

3. Tamm-Horsfall-Protein excretion as a marker of ascending limb transport indicates early renal tubular damage in diabetes mellitus type I.

Review 4. Type 1 diabetes and coronary artery disease.

5. Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.

6. Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children.

7. The value of uromodulin as a new serum marker to predict decline in renal function.

Review 8. Uromodulin: from monogenic to multifactorial diseases.

9. Measures of arterial stiffness in youth with type 1 and type 2 diabetes: the SEARCH for diabetes in youth study.

10. Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study.

1. Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes.

Review 2. Cardiovascular disease in young People with Type 1 Diabetes: Search for Cardiovascular Biomarkers.