Literature DB >> 3100333

Clostridium botulinum type C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin.

K Aktories, U Weller, G S Chhatwal.   

Abstract

The culture medium of certain strains of Clostridium botulinum type C contains two separable ADP-ribosyltransferases. Besides the ADP-ribosylation of actin due to botulinum C2 I toxin, a second microbial enzyme causes the mono-ADP-ribosylation of a eukaryotic protein with a molecular mass of about 20 kDa found in platelets, neuroblastoma X glioma hybrid cells, S49 lymphoma cells, chick embryo fibroblasts and sperm. The eukaryotic substrate is inactivated by heating and trypsin treatment. In contrast, the novel ADP-ribosyltransferase, which can be separated by DEAE-Sephadex chromatography, is largely resistant in the short term to trypsin digestion.

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Year:  1987        PMID： 3100333     DOI： 10.1016/0014-5793(87)81566-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  42 in total

1.  Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases.

Authors:  J Aoki; H Katoh; H Yasui; Y Yamaguchi; K Nakamura; H Hasegawa; A Ichikawa; M Negishi
Journal:  Biochem J       Date:  1999-06-01       Impact factor: 3.857

Review 2.  Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens.

Authors:  Alexander E Lang; Gudula Schmidt; Joel J Sheets; Klaus Aktories
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-11-12       Impact factor: 3.000

Review 3.  Clostridial ADP-ribosyltransferases--modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins.

Authors:  K Aktories
Journal:  Med Microbiol Immunol       Date:  1990       Impact factor: 3.402

4.  TNF-α induces dyscohesion of epithelial cells. Association with disassembly of actin filaments.

Authors:  S Tabibzadeh; Q F Kong; S Kapur; H Leffers; A Ridley; K Aktories; J E Celis
Journal:  Endocrine       Date:  1995-08       Impact factor: 3.633

Review 5.  C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins.

Authors:  Martin Vogelsgesang; Alexander Pautsch; Klaus Aktories
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2006-12-05       Impact factor: 3.000

6.  Localization of the C3-Like ADP-ribosyltransferase from Staphylococcus aureus during bacterial invasion of mammalian cells.

Authors:  Gabriella Molinari; Manfred Rohde; Christian Wilde; Ingo Just; Klaus Aktories; Gursharan S Chhatwal
Journal:  Infect Immun       Date:  2006-06       Impact factor: 3.441

7.  Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

Authors:  F M Donovan; C J Pike; C W Cotman; D D Cunningham
Journal:  J Neurosci       Date:  1997-07-15       Impact factor: 6.167

8.  Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology.

Authors:  P Penzes; R C Johnson; V Kambampati; R E Mains; B A Eipper
Journal:  J Neurosci       Date:  2001-11-01       Impact factor: 6.167

Review 9.  Botulinum toxins--cause of botulism and systemic diseases?

Authors:  H Böhnel; F Gessler
Journal:  Vet Res Commun       Date:  2005-05       Impact factor: 2.459

10.  ADP-ribosylation of the GTP-binding protein Rho by Clostridium limosum exoenzyme affects basal, but not N-formyl-peptide-stimulated, actin polymerization in human myeloid leukaemic (HL60) cells.

Authors:  G Koch; J Norgauer; K Aktories
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857
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