Sefer Ustebay1, Yakup Baykus2, Rulin Deniz2, Kader Ugur3, Seyda Yavuzkir4, Meltem Yardim5, Mehmet Kalayci5, Mete Çaglar6, Suleyman Aydin5. 1. 1 Department of Pediatrics, School of Medicine, Kafkas University, Kars, Turkey. 2. 2 Department of Obstetrics and Gynecology, School of Medicine, Kafkas University, Kars, Turkey. 3. 3 Department of Internal Medicine (Endocrinology and Metabolism Diseases), School of Medicine, Firat University, Elazig, Turkey. 4. 4 Department of Obstetrics and Gynecology, School of Medicine, Firat University, Elazig, Turkey. 5. 5 Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Medical School, Firat University, Elazig, Turkey. 6. 6 Department of Obstetrics and Gynecology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Abstract
BACKGROUND: Chemerin and dermcidin, which have antimicrobial properties, are molecules that are also related to insulin resistance and inflammation. RESEARCH AIMS: The aims were to determine the amounts of chemerin and dermcidin in the milk and blood of mothers with gestational diabetes, and to compare the amounts of chemerin and dermcidin in the milk and blood of mothers with and without diabetes. METHODS: This was a two-group nonrandomized longitudinal study with a convenience sampling of mothers without gestational diabetes (n = 27) and mothers with gestational diabetes (n = 26). Human milk and blood samples were obtained from these mothers during colostrum, transitional, and mature milk periods. The amount of chemerin and dermcidin in these samples was measured by enzyme-linked immunosorbent assay. RESULTS: The presence of chemerin and dermcidin was first detected in human milk. The amounts of chemerin and dermcidin in the blood of all the mothers were greater in the colostrum period and lowest in the mature period. The amount of chemerin and dermcidin in the milk of all the mothers was greater than that in the blood. The amounts of chemerin and dermcidin were significantly increased in both blood and human milk within the gestational age samples. CONCLUSIONS: Chemerin and dermcidin may contribute to the protection of infants from infections during infancy. Increased amounts of these molecules found within the gestational diabetes group may also prevent adverse maternal and fetal outcomes.
BACKGROUND: Chemerin and dermcidin, which have antimicrobial properties, are molecules that are also related to insulin resistance and inflammation. RESEARCH AIMS: The aims were to determine the amounts of chemerin and dermcidin in the milk and blood of mothers with gestational diabetes, and to compare the amounts of chemerin and dermcidin in the milk and blood of mothers with and without diabetes. METHODS: This was a two-group nonrandomized longitudinal study with a convenience sampling of mothers without gestational diabetes (n = 27) and mothers with gestational diabetes (n = 26). Human milk and blood samples were obtained from these mothers during colostrum, transitional, and mature milk periods. The amount of chemerin and dermcidin in these samples was measured by enzyme-linked immunosorbent assay. RESULTS: The presence of chemerin and dermcidin was first detected in human milk. The amounts of chemerin and dermcidin in the blood of all the mothers were greater in the colostrum period and lowest in the mature period. The amount of chemerin and dermcidin in the milk of all the mothers was greater than that in the blood. The amounts of chemerin and dermcidin were significantly increased in both blood and human milk within the gestational age samples. CONCLUSIONS: Chemerin and dermcidin may contribute to the protection of infants from infections during infancy. Increased amounts of these molecules found within the gestational diabetes group may also prevent adverse maternal and fetal outcomes.
Entities:
Keywords:
breastfeeding; colostrum; hormones; human milk
Authors: Mohammad Muzaffar Mir; Rashid Mir; Mushabab Ayed Abdullah Alghamdi; Javed Iqbal Wani; Zia Ul Sabah; Mohammed Jeelani; Vijaya Marakala; Shahzada Khalid Sohail; Mohamed O'haj; Muffarah Hamid Alharthi; Mohannad Mohammad S Alamri Journal: J Pers Med Date: 2022-05-01
Authors: Majed A Suwaydi; Xiaojie Zhou; Sharon L Perrella; Mary E Wlodek; Ching Tat Lai; Zoya Gridneva; Donna T Geddes Journal: Nutrients Date: 2022-09-01 Impact factor: 6.706