Efficacy of Application of Platelet-Rich Fibrin for Improvement of Implant Stability: A Clinical Trial.

Use of platelet concentrates to increase implant stability, due to their regenerative potential, has recently attracted the attention of researchers. This study aimed to assess the effect of platelet-rich fibrin (PRF) on dental implant stability. This clinical trial evaluated 10 patients who received 50 dental implants. Each patient received at least two implants. Half of the implants were placed in the sockets along with PRF while the remaining half were inserted conventionally without PRF. Implant stability was measured by resonance frequency analysis on the day of surgery (T1), at one week (T2), and at one month (T3). At the end of the first week (T2), the mean implant stability quotient (ISQ) was 59.85 ± 5.32 in the PRF group and 55.99 ± 3.39 in the non-PRF group. Compared to baseline, the ISQ increased in the PRF group by 0.12 ± 0.47 (P = 1.000) and decreased in the non-PRF group by 2.42 ± 0.36 (P < 0.001). At one month postoperatively, ISQ significantly increased by 6.89 ± 0.96 in the PRF group and by 4.82 ± 0.92 in the non-PRF group compared to baseline (P < 0.001). Application of PRF in the implant osteotomy site can prevent or minimize primary reductions in implant stability and seems to enhance the process of osseointegration.