Literature DB >> 31002282

Myocardial ischemia: lack of coronary blood flow, myocardial oxygen supply-demand imbalance, or what?

Gerd Heusch1.   

Abstract

This opinionated article reviews current concepts of myocardial ischemia. Specifically, the historical background is briefly presented. Then, the prevailing paradigm of myocardial oxygen-supply-demand imbalance is criticized since demand is a virtual parameter that cannot be measured and data on measurements of myocardial blood flow and contractile function rather support matching between flow and function. Finally, a concept of myocardial ischemia that focusses on the reduction of coronary blood flow to below 8-10 µl/g per beat with consequences for myocardial electrical, metabolic, contractile and morphological features is advocated.

Entities:  

Keywords:  coronary blood flow; hibernation; myocardial infarction; myocardial ischemia; reperfusion; stunning

Mesh：

Substances：

Year:  2019        PMID： 31002282      PMCID： PMC7137753          DOI： 10.1152/ajpheart.00139.2019

Source DB:  PubMed          Journal:  Am J Physiol Heart Circ Physiol        ISSN： 0363-6135            Impact factor:   4.733


  88 in total

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Journal:  Circ Res       Date:  1985-05       Impact factor: 17.367

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Authors: 
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Review 8.  Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.

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Journal:  Eur Heart J Acute Cardiovasc Care       Date:  2019-02-14

Review 9.  Cardiovascular remodelling in coronary artery disease and heart failure.

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Journal:  Tissue Eng Regen Med       Date:  2020-03-29       Impact factor: 4.169

5.  Role of coronary flow regulation and cardiac-coronary coupling in mechanical dyssynchrony associated with right ventricular pacing.

Authors:  Lei Fan; Ravi Namani; Jenny S Choy; Yousif Awakeem; Ghassan S Kassab; Lik Chuan Lee
Journal:  Am J Physiol Heart Circ Physiol       Date:  2020-12-24       Impact factor: 4.733

Review 6.  Application of stem cell-derived exosomes in ischemic diseases: opportunity and limitations.

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Journal:  J Transl Med       Date:  2021-05-08       Impact factor: 5.531

7.  CircANXA2 Promotes Myocardial Apoptosis in Myocardial Ischemia-Reperfusion Injury via Inhibiting miRNA-133 Expression.

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8.  Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease.

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Review 9.  A pathophysiological compass to personalize antianginal drug treatment.

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10.  Phosphorylation in Novel Mitochondrial Creatine Kinase Tyrosine Residues Render Cardioprotection against Hypoxia/Reoxygenation Injury.

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