Literature DB >> 30999307

Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?

Emmanuel Dudoignon1,2, François Dépret1,2,3, Matthieu Legrand4,5,6.   

Abstract

The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Effects of RAAS antagonists are variable in chronic or acute conditions. The aim of this review is to discuss the renal and systemic effects of the RAAS, and its modulation, in acute situations.
© 2019 S. Karger AG, Basel.

Entities:  

Keywords:  Acute conditions; Acute kidney injury; Antagonists; Chronic conditions; Renal fibrosis; Renin-angiotensin-aldosterone system

Mesh：

Substances：

Year:  2019        PMID： 30999307     DOI： 10.1159/000499940

Source DB:  PubMed          Journal:  Nephron        ISSN： 1660-8151            Impact factor:   2.847


  4 in total

1.  Role of protease-activated receptor 2 in regulation of renin synthesis and secretion in mice.

Authors:  Lena R Thurner; Klaus Höcherl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-06-27       Impact factor: 3.000

2.  Impact of contrast-induced acute kidney injury on the association between renin-angiotensin system inhibitors and long-term mortality in heart failure patients.

Authors:  Li Lei; Yulu Huang; Zhaodong Guo; Feier Song; Yibo He; Jin Liu; Guoli Sun; Bowen Liu; Pengyuan Chen; Jianbin Zhao; Dengxuan Wu; Yan Xue; Wenhe Yan; Zefeng Lin; Xiuqiong Huang; Guanzhong Chen; Shiqun Chen; Yong Liu; Jiyan Chen
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2020 Oct-Dec       Impact factor: 1.636

3.  Diurnal rhythms of urine volume and electrolyte excretion in healthy young men under differing intensities of daytime light exposure.

Authors:  Isuzu Nakamoto; Sayaka Uiji; Rin Okata; Hisayoshi Endo; Sena Tohyama; Rina Nitta; Saya Hashimoto; Yoshiko Matsushima; Junko Wakimoto; Seiji Hashimoto; Yukiko Nishiyama; Dominika Kanikowska; Hiromitsu Negoro; Tomoko Wakamura
Journal:  Sci Rep       Date:  2021-06-23       Impact factor: 4.379

Review 4.  Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems.

Authors:  Joshua J Scammahorn; Isabel T N Nguyen; Eelke M Bos; Harry Van Goor; Jaap A Joles
Journal:  Antioxidants (Basel)       Date:  2021-03-02
  4 in total

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