Literature DB >> 30996810

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.

Deborah Quaglio1, Nadezda Zhdanovskaya2, Gloria Tobajas3, Viviana Cuartas3, Silvia Balducci1, Michael S Christodoulou4, Giancarlo Fabrizi1, Marta Gargantilla3, Eva-María Priego3, Álvaro Carmona Pestaña2, Daniele Passarella5, Isabella Screpanti2, Bruno Botta1, Rocco Palermo2, Mattia Mori6, Francesca Ghirga7, María-Jesús Pérez-Pérez3.   

Abstract

Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.

Entities:  

Year:  2019        PMID： 30996810      PMCID： PMC6466818          DOI： 10.1021/acsmedchemlett.8b00608

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  19 in total

1.  Selective methoxy ether cleavage of 2,6-dimethoxyphenol followed by a selective acylation.

Authors:  Enoch A Adogla; Romy F J Janser; Samuel S Fairbanks; Caitlyn M Vortolomei; Ranjith K Meka; Ingo Janser
Journal:  Tetrahedron Lett       Date:  2012-01-04       Impact factor: 2.415

2.  Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Authors:  Andrew P Weng; Adolfo A Ferrando; Woojoong Lee; John P Morris; Lewis B Silverman; Cheryll Sanchez-Irizarry; Stephen C Blacklow; A Thomas Look; Jon C Aster
Journal:  Science       Date:  2004-10-08       Impact factor: 47.728

Review 3.  The canonical Notch signaling pathway: unfolding the activation mechanism.

Authors:  Raphael Kopan; Maria Xenia G Ilagan
Journal:  Cell       Date:  2009-04-17       Impact factor: 41.582

Review 4.  Stem cells living with a Notch.

Authors:  Ute Koch; Rajwinder Lehal; Freddy Radtke
Journal:  Development       Date:  2013-02       Impact factor: 6.868

Review 5.  Notch signaling in the regulation of stem cell self-renewal and differentiation.

Authors:  Jianing Liu; Chihiro Sato; Massimiliano Cerletti; Amy Wagers
Journal:  Curr Top Dev Biol       Date:  2010       Impact factor: 4.897

Review 6.  Targeting notch signaling pathway in cancer: clinical development advances and challenges.

Authors:  Naoko Takebe; Dat Nguyen; Sherry X Yang
Journal:  Pharmacol Ther       Date:  2013-09-27       Impact factor: 12.310

7.  Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.

Authors:  Diana Bellavia; Antonio F Campese; Saula Checquolo; Anna Balestri; Andrea Biondi; Giovanni Cazzaniga; Urban Lendahl; Hans J Fehling; Adrian C Hayday; Luigi Frati; Harald von Boehmer; Alberto Gulino; Isabella Screpanti
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

8.  Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

Authors:  Sudhir S Rao; Jennifer O'Neil; Cole D Liberator; James S Hardwick; Xudong Dai; Theresa Zhang; Edyta Tyminski; Jing Yuan; Nancy E Kohl; Victoria M Richon; Lex H T Van der Ploeg; Pamela M Carroll; Giulio F Draetta; A Thomas Look; Peter R Strack; Christopher G Winter
Journal:  Cancer Res       Date:  2009-03-24       Impact factor: 12.701

9.  Notch signaling is necessary for epithelial growth arrest by TGF-beta.

Authors:  Hideki Niimi; Katerina Pardali; Michael Vanlandewijck; Carl-Henrik Heldin; Aristidis Moustakas
Journal:  J Cell Biol       Date:  2007-02-26       Impact factor: 10.539

Review 10.  Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Authors:  Subhash Padhye; Aamir Ahmad; Nikhil Oswal; Fazlul H Sarkar
Journal:  J Hematol Oncol       Date:  2009-09-02       Impact factor: 17.388
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  4 in total

1.  Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia.

Authors:  Yang Li; Ying Sun; Yang Zhou; Xinyang Li; Huan Zhang; Guojun Zhang
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

Review 2.  The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections.

Authors:  Floriana Cappiello; Maria Rosa Loffredo; Cristina Del Plato; Silvia Cammarone; Bruno Casciaro; Deborah Quaglio; Maria Luisa Mangoni; Bruno Botta; Francesca Ghirga
Journal:  Antibiotics (Basel)       Date:  2020-06-13

Review 3.  Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections.

Authors:  Bruno Casciaro; Laura Mangiardi; Floriana Cappiello; Isabella Romeo; Maria Rosa Loffredo; Antonia Iazzetti; Andrea Calcaterra; Antonella Goggiamani; Francesca Ghirga; Maria Luisa Mangoni; Bruno Botta; Deborah Quaglio
Journal:  Molecules       Date:  2020-08-09       Impact factor: 4.411

4.  The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria.

Authors:  Bruno Casciaro; Francesca Ghirga; Floriana Cappiello; Valeria Vergine; Maria Rosa Loffredo; Silvia Cammarone; Elena Puglisi; Carola Tortora; Deborah Quaglio; Mattia Mori; Bruno Botta; Maria Luisa Mangoni
Journal:  Antibiotics (Basel)       Date:  2022-01-11
  4 in total

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