| Literature DB >> 30996789 |
Stefano Palazzolo1,2,3, Mohamad Hadla1, Concetta Russo Spena1, Samer Bayda1, Vinit Kumar1,4, Francesco Lo Re1, Muhammad Adeel3, Isabella Caligiuri3, Flavio Romano5, Giuseppe Corona1, Vincenzo Canzonieri3,5, Giuseppe Toffoli1, Flavio Rizzolio1,3,6.
Abstract
One of the most promising applications of DNA origami is its use as an excellent evolution of nanostructured intelligent systems for drug delivery, but short in vivo lifetime and immune-activation are still major challenges to overcome. On the contrary, stealth liposomes have long-circulation time and are well tolerated by the immune system. To overcome DNA origami limitations, we have designed and synthesized a compact short tube DNA origami (STDO) of approximately 30 nm in length and 10 nm in width. These STDO are highly stable ≥48 h in physiological conditions without any postsynthetic modifications. The compact size of STDO precisely fits inside a stealthy liposome of about 150 nm and could efficiently remotely load doxorubicin in liposomes (LSTDO) without a pH driven gradient. We demonstrated that this innovative drug delivery system (DDS) has an optimal tumoral release and high biocompatible profiles opening up new horizons to encapsulate many other hydrophobic drugs.Entities:
Year: 2019 PMID： 30996789 PMCID： PMC6466551 DOI： 10.1021/acsmedchemlett.8b00557
Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345