| Literature DB >> 30996773 |
Marina Massaro1, Gabriella Buscemi1, Luca Arista2, Giuseppa Biddeci1,3, Giuseppe Cavallaro4, Francesca D'Anna1, Francesco Di Blasi3, Angelo Ferrante5, Giuseppe Lazzara4, Carla Rizzo1, Gaetano Spinelli3, Thomas Ullrich2, Serena Riela1.
Abstract
A novel carrier system based on halloysite nanotubes (HNT), for the potential intraarticular delivery of kartogenin (KGN) by means laponite (Lap) hydrogel (HNT/KGN/Lap), is developed. The drug was first loaded into HNT, and the hybrid composite obtained was used as filler for laponite hydrogel. Both the filler and the hydrogel were thoroughly investigated by several techniques and the hydrogel morphology was imaged by transmission electron microscopy. Furthermore, the gelating ability of laponite in the presence of the filler and the rheological properties of the hybrid hydrogel were also investigated. The kinetic release of kartogenin from HNT and HNT/Lap hybrid hydrogel was studied both in physiological conditions and in ex vivo synovial fluid. In the last case, the kinetic results highlighted that HNT carrier can effectively release KGN in a sustained manner for at least 38 days. Finally, a preliminary biological assays showed that the HNT/KGN/Lap hybrid hydrogel did not exhibit any cytotoxic effect.Entities:
Year: 2018 PMID： 30996773 PMCID： PMC6466553 DOI： 10.1021/acsmedchemlett.8b00465
Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345