Fiona J Rowe1, Lauren R Hepworth2, Elizabeth J Conroy3, Naomi E A Rainford3, Emma Bedson4, Avril Drummond5, Marta García-Fiñana3, Claire Howard6, Alex Pollock7, Tracey Shipman8, Caroline Dodridge9, Stevie Johnson10, Carmel Noonan11, Catherine Sackley12. 1. Department of Health Services Research, University of Liverpool, Liverpool, L69 3GB, UK. rowef@liverpool.ac.uk. 2. Department of Health Services Research, University of Liverpool, Liverpool, L69 3GB, UK. 3. Department of Biostatistics, University of Liverpool, Liverpool, L69 3GA, UK. 4. Clinical Trials Research Unit, University of Liverpool, Liverpool, L69 3GL, UK. 5. School of Health Sciences, University of Nottingham, Nottingham, NG7 2UH, UK. 6. Department of Orthoptics, Salford Royal NHS Foundation Trust, Manchester, M6 8HD, UK. 7. Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, G4 0BA, UK. 8. Department of Orthoptics, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK. 9. Department of Orthoptics, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK. 10. Eye Clinic Support Service, Royal National Institute of Blind People, Birmingham, B29 6NA, UK. 11. Department of Ophthalmology, Aintree University Hospital NHS Foundation Trust, Liverpool, L9 7AL, UK. 12. Division of Health and Social Care, King's College, London, WC2B 5RL, UK.
Abstract
BACKGROUND: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. METHODS: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. RESULTS:Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was 'driving' whilst the least impacted were 'colour vision' and 'ocular pain'. CONCLUSIONS:Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. TRIAL REGISTRATION: Current Controlled Trials ISRCTN05956042.
RCT Entities:
BACKGROUND: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. METHODS: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. RESULTS: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was 'driving' whilst the least impacted were 'colour vision' and 'ocular pain'. CONCLUSIONS: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. TRIAL REGISTRATION: Current Controlled Trials ISRCTN05956042.
Authors: F J Rowe; E J Conroy; E Bedson; E Cwiklinski; A Drummond; M García-Fiñana; C Howard; A Pollock; T Shipman; C Dodridge; C MacIntosh; S Johnson; C Noonan; G Barton; C Sackley Journal: Acta Neurol Scand Date: 2016-12-27 Impact factor: 3.209
Authors: Lina Aimola; Alison R Lane; Daniel T Smith; Georg Kerkhoff; Gary A Ford; Thomas Schenk Journal: Neurorehabil Neural Repair Date: 2013-09-18 Impact factor: 3.919