Lijuan Luo1, Lile Zou2, Wenbin Dong1, Yuan He1, Huan Yu1, Xiaoping Lei3. 1. Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. 2. Department of Histology and Embryology, Southwest Medical University, Luzhou, Sichuan, China. 3. Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. leixiaopingde@126.com.
Abstract
BACKGROUND: Serum bilirubin levels are inversely associated with obesity in adults. We are interested in whether neonatal jaundice is associated with childhood obesity in preterm infants. METHODS: Data were obtained from the US Collaborative Perinatal Project. Neonatal bilirubin levels were used as exposure factors for obesity at age 7 years. Logistic regression models were used to control for potential confounders and calculate odds ratios (ORs). A generalized estimating equation (GEE) model was used to correct for intracluster correlation coefficient. SAS was used for all statistical analyses. RESULTS: In the study subjects, 865 of 5019 preterm infants were obese at age 7 years. While neonatal total serum bilirubin (TSB) rose 1 mg/dl, body mass index (BMI) increased 0.03 kg/m2 (95% confidence interval (CI) 0.02, 0.04). Compared with infants with TSB <3 mg/dl, the ORs (95% CIs) for obesity in infants with 3 mg/dl≤ TSB <6 mg/dl, 6 mg/dl≤ TSB <9 mg/dl, 9 mg/dl≤ TSB <12 mg/dl and TSB ≥12 mg/dl were, respectively, 1.18 (0.87, 1.59), 1.25 (0.93, 1.67), 1.52 (1.11, 2.09), and 1.67 (1.22, 2.07). By using subtypes of bilirubin as exposure factors and the GEE model to correct for intracluster correlation coefficient, similar trends of associations were observed. CONCLUSION: Neonatal bilirubin levels have positive trends of associations with childhood obesity in preterm infants.
BACKGROUND: Serum bilirubin levels are inversely associated with obesity in adults. We are interested in whether neonatal jaundice is associated with childhood obesity in preterm infants. METHODS: Data were obtained from the US Collaborative Perinatal Project. Neonatal bilirubin levels were used as exposure factors for obesity at age 7 years. Logistic regression models were used to control for potential confounders and calculate odds ratios (ORs). A generalized estimating equation (GEE) model was used to correct for intracluster correlation coefficient. SAS was used for all statistical analyses. RESULTS: In the study subjects, 865 of 5019 preterm infants were obese at age 7 years. While neonatal total serum bilirubin (TSB) rose 1 mg/dl, body mass index (BMI) increased 0.03 kg/m2 (95% confidence interval (CI) 0.02, 0.04). Compared with infants with TSB <3 mg/dl, the ORs (95% CIs) for obesity in infants with 3 mg/dl≤ TSB <6 mg/dl, 6 mg/dl≤ TSB <9 mg/dl, 9 mg/dl≤ TSB <12 mg/dl and TSB ≥12 mg/dl were, respectively, 1.18 (0.87, 1.59), 1.25 (0.93, 1.67), 1.52 (1.11, 2.09), and 1.67 (1.22, 2.07). By using subtypes of bilirubin as exposure factors and the GEE model to correct for intracluster correlation coefficient, similar trends of associations were observed. CONCLUSION: Neonatal bilirubin levels have positive trends of associations with childhood obesity in preterm infants.
Authors: H J Vreman; J Verter; W Oh; A A Fanaroff; L L Wright; J A Lemons; S Shankaran; J E Tyson; S B Korones; C R Bauer; B J Stoll; L A Papile; E F Donovan; R A Ehrenkranz; D K Stevenson Journal: Clin Chem Date: 1996-06 Impact factor: 8.327