Literature DB >> 30994906

Serum S100A8/A9 as a Potentially Sensitive Biomarker for Inflammatory Bowel Disease.

Kohki Okada1,2, Makoto Okabe3, Yuto Kimura4, Hiroshi Itoh5, Masaki Ikemoto5.   

Abstract

BACKGROUND: The clinical significance of human S100A8/A9 (h-S100A8/A9) in patients with inflammatory bowel disease (IBD) is poorly understood.
OBJECTIVE: To clarify whether serum S100A8/A9 is a sensitive biomarker for IBD.
METHODS: Serum specimens from outpatients with IBD (n = 101) and healthy volunteers (HVs) (n = 101) were used in this study. Enzyme-linked immunosorbent assays for h-S100A8/A9 and inflammatory cytokines were performed using these specimens. Further, correlation analysis was performed to investigate the significance of h-S100A8/A9 fluctuation in patients with IBD.
RESULTS: The average of serum h-S100A8/A9 concentration in outpatients with IBD was significantly higher than that in HVs. The concentration of h-S100A8/A9 in patients with IBD was barely correlated with that of CRP and inflammatory cytokines. Despite that finding, the serum level of h-S100A8/A9 in patients with ulcerative colitis (UC) was correlated with the severity of IBD, compared with other inflammatory proteins.
CONCLUSION: Serum h-S100A8/A9 is superior to CRP as a sensitive biomarker for IBD. © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  C-reactive protein; biomarker; h-S100A8/A9; inflammatory bowel disease; inflammatory cytokines, enzyme-linked immunosorbent assay

Year:  2019        PMID： 30994906     DOI： 10.1093/labmed/lmz003

Source DB:  PubMed          Journal:  Lab Med        ISSN： 0007-5027


  9 in total

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5.  Serum complement C3 and α2-macroglobulin are potentially useful biomarkers for inflammatory bowel disease patients.

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6.  Carbonic Anhydrase III Has Potential as a Biomarker for Experimental Colitis and Functions as an Immune Regulator by Inhibiting Inflammatory Cytokine Secretion.

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8.  Circulating S100A8/A9 is potentially a biomarker that could reflect the severity of experimental colitis in rats.

Authors:  Kohki Okada; Hiroshi Itoh; Masaki Ikemoto
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9.  FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis.

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