Sebastian Vernal1, Roberto Bueno-Filho1, Ciro Martins Gomes2, Ana Maria Roselino1. 1. Divisão de Dermatologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil. 2. Departamento de Dermatologia, Universidade de Brasília, Brasília, DF, Brasil.
Abstract
INTRODUCTION: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce. METHODS: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of coinfection with both diseases. RESULTS: Nine patients with leishmaniasis (5 cutaneous, 3 mucocutaneous, 1 disseminated case) exhibited concurrent infection with distinct clinical forms of leprosy. Our diagram-based analysis evidenced a divergent clinico-immunological spectrum for each disease in 8 out of 9 cases. CONCLUSIONS: The spectrum of ATL-leprosy comorbidity suggests that the host has a specific immune response against each pathogen.
INTRODUCTION: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce. METHODS: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of coinfection with both diseases. RESULTS: Nine patients with leishmaniasis (5 cutaneous, 3 mucocutaneous, 1 disseminated case) exhibited concurrent infection with distinct clinical forms of leprosy. Our diagram-based analysis evidenced a divergent clinico-immunological spectrum for each disease in 8 out of 9 cases. CONCLUSIONS: The spectrum of ATL-leprosy comorbidity suggests that the host has a specific immune response against each pathogen.
Authors: Amanda Gabriela de Carvalho; João Gabriel Guimarães Luz; Peter Steinmann; Eliane Ignotti Journal: Rev Inst Med Trop Sao Paulo Date: 2022-06-06 Impact factor: 2.169
Authors: Amanda Gabriela de Carvalho; Anuj Tiwari; João Gabriel Guimarães Luz; Daan Nieboer; Peter Steinmann; Jan Hendrik Richardus; Eliane Ignotti Journal: PLoS Negl Trop Dis Date: 2021-12-13