| Literature DB >> 309946 |
J Ackrell, Y Antonio, F Franco, R Landeros, A Leon, J M Muchowski, M L Maddox, P H Nelson, W H Rooks, A P Roszkowski, M B Wallach.
Abstract
Acetic acid derivatives of tricyclic systems, such as 6,11-dihydro-11-oxodibenzo[b,e]thiepin, 4,10-dihydro-4-oxo-thieno[2,3-c][1]benzothiepin, dibenzo[b,f]thiepin, dibenz[b,f]oxepin, etc., were synthesized and assayed for antiinflammatory activity. One of the compounds, 6,11-dihydro-11-oxodibenzo[b,e]thiepin-3-acetic acid (52), was chosen for evaluation in man on the basis of high antiinflammatory activity in both short- and long-term animal assays and a low gastric irritation liability in rats and dogs.Entities:
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Year: 1978 PMID： 309946 DOI： 10.1021/jm00208a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446