| Literature DB >> 3099423 |
G Thomas, V A Skrinska, F V Lucas.
Abstract
The platelet membrane contains sulfhydryl groups which are essential for normal platelet function. Reduced glutathione (GSH) and other thiols such as cysteine and 6-mercaptopurine were found to inhibit human platelet aggregation induced by adenosine diphosphate (ADP), collagen and arachidonic acid. The inhibition of ADP-induced aggregation by GSH (IC50 = 0.61 +/- 0.05 mM) was greater than that by cysteine (IC50 = 13 +/- 1 mM) or 6-mercaptopurine (IC50 = 5.4 +/- 0.2 mM). Two other thiols, dithiothreitol and beta-mercaptoethanol were found to cause platelet aggregation instead of inhibition. The interaction of GSH with the ADP receptor was noncompetitive in nature.Entities:
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Year: 1986 PMID： 3099423 DOI： 10.1016/0049-3848(86)90031-9
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944