Literature DB >> 3099330

Gastric mucosal binding studies with enprostil: a potent anti-ulcer prostaglandin.

S K Woo, P Roszkowski, L D Waterbury, G L Garay.   

Abstract

The potent antiulcer prostaglandin enprostil binds with high affinity to porcine gastric mucosal tissues. This binding is saturable, dissociable and displaceable by compounds with similar structures. Various characteristics of binding such as pH optimum and displacement potencies suggest that enprostil binds to mucosal PGE2 sites. Structure-activity and gastric mucosal binding relationships were also examined.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3099330     DOI： 10.1016/0090-6980(86)90129-2

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  4 in total

1.  Binding and biological actions of prostaglandin E2 and I2 in cells isolated from rabbit gastric mucosa.

Authors:  D B Barr; J A Duncan; J A Kiernan; B D Soper; B L Tepperman
Journal:  J Physiol       Date:  1988-11       Impact factor: 5.182

2.  Characterization of the prostanoid receptor profile of enprostil and isomers in smooth muscle and platelets in vitro.

Authors:  R M Eglen; R L Whiting
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

3.  Stimulation of glycoprotein and protein synthesis in isolated pig gastric mucosal cells by prostaglandins.

Authors:  H K Heim; A Oestmann; K F Sewing
Journal:  Gut       Date:  1990-04       Impact factor: 23.059

Review 4.  Enprostil. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease.

Authors:  K L Goa; J P Monk
Journal:  Drugs       Date:  1987-11       Impact factor: 9.546
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.