Literature DB >> 30992270

Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis.

Cuong Quang Le1, Greggory Myers2, Alawi Habara1,3, Natee Jearawiriyapaisarn4, George J Murphy1,5, David H K Chui1, Martin H Steinberg1, James Douglas Engel2, Shuaiying Cui1.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 30992270      PMCID： PMC6543516          DOI： 10.1182/blood.2018892737

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


× No keyword cloud information.
  23 in total

1.  Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.

Authors:  Min Gyu Lee; Christopher Wynder; Dawn M Schmidt; Dewey G McCafferty; Ramin Shiekhattar
Journal:  Chem Biol       Date:  2006-06

2.  In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds.

Authors:  J Shuga; J Zhang; L D Samson; H F Lodish; L G Griffith
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-14       Impact factor: 11.205

Review 3.  Sickle Cell Disease.

Authors:  Frédéric B Piel; Martin H Steinberg; David C Rees
Journal:  N Engl J Med       Date:  2017-04-20       Impact factor: 91.245

4.  Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes.

Authors:  Shuaiying Cui; Osamu Tanabe; Michael Sierant; Lihong Shi; Andrew Campbell; Kim-Chew Lim; James Douglas Engel
Journal:  Blood       Date:  2015-01-05       Impact factor: 22.113

5.  Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.

Authors:  Shuaiying Cui; Katarzyna E Kolodziej; Naoshi Obara; Alexandra Amaral-Psarris; Jeroen Demmers; Lihong Shi; James Douglas Engel; Frank Grosveld; John Strouboulis; Osamu Tanabe
Journal:  Mol Cell Biol       Date:  2011-06-13       Impact factor: 4.272

6.  Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.

Authors:  Andrew D Campbell; Shuaiying Cui; Lihong Shi; Rebekah Urbonya; Andrea Mathias; Kori Bradley; Kwaku O Bonsu; Rhonda R Douglas; Brittne Halford; Lindsay Schmidt; David Harro; Donald Giacherio; Keiji Tanimoto; Osamu Tanabe; James Douglas Engel
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-31       Impact factor: 11.205

7.  The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).

Authors:  Angela Rivers; Kestis Vaitkus; Vinzon Ibanez; Maria Armila Ruiz; Ramasamy Jagadeeswaran; Yogen Saunthararajah; Shuaiying Cui; James D Engel; Joseph DeSimone; Donald Lavelle
Journal:  Haematologica       Date:  2016-02-08       Impact factor: 9.941

8.  Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.

Authors:  Maria Amaya; Megha Desai; Merlin Nithya Gnanapragasam; Shou Zhen Wang; Sheng Zu Zhu; David C Williams; Gordon D Ginder
Journal:  Blood       Date:  2013-02-26       Impact factor: 22.113

9.  Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology.

Authors:  Soyoung Lim; Andreas Janzer; Astrid Becker; Andreas Zimmer; Roland Schüle; Reinhard Buettner; Jutta Kirfel
Journal:  Carcinogenesis       Date:  2009-12-30       Impact factor: 4.944

10.  A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells.

Authors:  Seonmi Park; Andreia Gianotti-Sommer; Francisco Javier Molina-Estevez; Kim Vanuytsel; Nick Skvir; Amy Leung; Sarah S Rozelle; Elmutaz Mohammed Shaikho; Isabelle Weir; Zhihua Jiang; Hong-Yuan Luo; David H K Chui; Maria Stella Figueiredo; Abdulraham Alsultan; Amein Al-Ali; Paola Sebastiani; Martin H Steinberg; Gustavo Mostoslavsky; George J Murphy
Journal:  Stem Cell Reports       Date:  2017-01-19       Impact factor: 7.765
View more
  2 in total

Review 1.  Fetal hemoglobin in sickle cell anemia.

Authors:  Martin H Steinberg
Journal:  Blood       Date:  2020-11-19       Impact factor: 22.113

2.  Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease.

Authors:  Aline Renata Pavan; Juliana Romano Lopes; Carlos Henrique Lima Imperador; Chung Man Chin; Jean Leandro Dos Santos
Journal:  Front Med (Lausanne)       Date:  2022-09-08
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.