| Literature DB >> 3099224 |
B Costall, M E Kelly, R J Naylor, C C Tan, F D Tattersall.
Abstract
The injection of 5-hydroxytryptamine (5-HT) and 2-methyl-5-HT into the perifornical area of the hypothalamus of the guinea-pig reduced the emptying of barium sulphate spheroids from the stomach. In contrast, the injection of the 5-HT M-receptor antagonist ICS 205-930 into the same area of the hypothalamus enhanced gastric emptying and attenuated the inhibitory effect of 5-HT. Similar injections of methysergide and ritanserin were without effect. It is concluded that an endogenous hypothalamic 5-HT system may inhibit gastric emptying through a 5-HT M-receptor mechanism which may afford a site of action for 5-HT agonist and antagonist drugs to modify gastric emptying.Entities:
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Year: 1986 PMID： 3099224 DOI： 10.1016/0028-3908(86)90151-6
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250