Hironori Otomune1, Masahito Mihara2, Noriaki Hattori1, Hiroaki Fujimoto1, Yuta Kajiyama3, Kuni Konaka4, Yukiko Mitani5, Yoshiyuki Watanabe6, Hideki Mochizuki7. 1. Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan; Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, 536-0025, Japan. 2. Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan; Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, 701-0192, Japan. Electronic address: mihara@med.kawasaki-m.ac.jp. 3. Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan. 4. Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan; Department of Physical Therapy, Faculty of Health Science, Osaka Yukioka College of Health Science, Osaka, 567-0801, Japan. 5. Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan; Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, 701-0192, Japan. 6. Department of Future Diagnostic Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan. 7. Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan. Electronic address: hmochizuki@neurol.med.osaka-u.ac.jp.
Abstract
INTRODUCTION: Gait and balance disorders are common clinical features of Parkinson's disease (PD). Although falls significantly affect the activities of daily living (ADL) and quality of life (QOL) of patients with PD, the underlying neural mechanisms associated with frequent falls in PD patients are still unclear. METHODS: Hypothesizing that the cerebral cortex would contribute to frequent falls in PD, we obtained 3D T1-weighted images from 91 non-dementia patients with PD and performed voxel-based morphometric analysis (VBM). Gray matter volume was compared between patients with and without frequent falls to investigate the structural basis for frequent falls in PD. As an ancillary analysis, we also performed resting-state functional magnetic resonance analysis using data from 58 patients. RESULTS: Among the 91 patients, 36 had experienced frequent falls. Gray matter volume in the right superior temporal gyrus (STG) and the right inferior parietal lobule (IPL) of these patients was significantly lower than that of the non-frequent fallers. There was also a significant correlation between fall frequency and gray matter volume in these two regions. Additionally, resting-state functional analysis revealed lower connectivity in the right posterior perisylvian region, including in the IPL and STG, in frequent fallers than in non-frequent fallers. CONCLUSION: Frequent falls in PD are associated with structural and functional abnormality of the cerebral cortex including the right IPL and STG.
INTRODUCTION: Gait and balance disorders are common clinical features of Parkinson's disease (PD). Although falls significantly affect the activities of daily living (ADL) and quality of life (QOL) of patients with PD, the underlying neural mechanisms associated with frequent falls in PDpatients are still unclear. METHODS: Hypothesizing that the cerebral cortex would contribute to frequent falls in PD, we obtained 3D T1-weighted images from 91 non-dementiapatients with PD and performed voxel-based morphometric analysis (VBM). Gray matter volume was compared between patients with and without frequent falls to investigate the structural basis for frequent falls in PD. As an ancillary analysis, we also performed resting-state functional magnetic resonance analysis using data from 58 patients. RESULTS: Among the 91 patients, 36 had experienced frequent falls. Gray matter volume in the right superior temporal gyrus (STG) and the right inferior parietal lobule (IPL) of these patients was significantly lower than that of the non-frequent fallers. There was also a significant correlation between fall frequency and gray matter volume in these two regions. Additionally, resting-state functional analysis revealed lower connectivity in the right posterior perisylvian region, including in the IPL and STG, in frequent fallers than in non-frequent fallers. CONCLUSION: Frequent falls in PD are associated with structural and functional abnormality of the cerebral cortex including the right IPL and STG.
Authors: Jin Hua Zheng; Wen Hua Sun; Jian Jun Ma; Zhi Dong Wang; Qing Qing Chang; Lin Rui Dong; Xiao Xue Shi; Ming Jian Li Journal: Clin Auton Res Date: 2022-01-20 Impact factor: 4.435
Authors: Jacek Wilczyński; Magdalena Ścipniak; Kacper Ścipniak; Kamil Margiel; Igor Wilczyński; Rafał Zieliński; Piotr Sobolewski Journal: Biomed Res Int Date: 2021-09-28 Impact factor: 3.411