Adriana Modesto1, Cristina Armbruster Jacas2, Sohyon Michelle Kim3, Alexander Desman4, Ilsa West5, Molly Lebow6, Caroline Littlejohn7, Kathleen Deeley8, Deborah Studen-Pavlovich9, Alexandre R Vieira10. 1. Dr. Modesto is a professor, chair and predoctoral program director, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA. 2. Ms. Armbruster Jacas, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA. 3. Dr. Kim is an assistant professor and predoctoral program director, Department of Orthodontics, School of Dentistry, Oregon Health and Science University, Portland, Ore., USA. 4. Dr. Desman is a orthodontic resident, Division of Orthodontics, College of Dentistry, The Ohio State University, Ohio, USA. 5. Dr. West is a pediatric dentist resident, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA. 6. Dr. Lebow is in private practice, both in Columbus, Ohio, USA. 7. Ms. Littlejohn are predoctoral students,School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA. 8. Ms. Deeley is a laboratory technician, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA. 9. Dr. Studen-Pavlovich is a professor and graduate program director, Department of Pediatric Dentistry. 10. Dr. Vieira is a professor, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA;, Email: ams208@pitt.edu.
Abstract
Purpose: The purpose of this study was to determine if dental ages are more advanced in overweight children and influenced by genetic variation. Methods: Panoramic radiographs from 577 children were obtained. For performing genetic studies, an additional 236 subjects had panoramic radiographs and whole saliva samples collected. Genotyping of IGF, FGF, and FGFR markers was done. Dental age was determined in 177 patients utilizing Demerjian's method and panoramic radiographs. Skeletal maturation was determined in 28 patients using Baccetti's cervical vertebral maturation method on lateral cephalograms. PLINK was used to test for over-representation of alleles. Results: FGF7, FGF10, and FGF13 were significantly associated with obesity (P = 0.02). When dental age was considered, overweight and obese children are more likely to have dental ages more advanced than their chronological ages (P = 0.05). An excess of heterozygotes of FGF18 rs4073716 was found in children with dental age more advanced than their chronological age (P=0.04). Conclusions: Overweight and obese children have dental ages more advanced than their chronological ages, and this occurrence may be influenced by genetic variation in FGF18.
Purpose: The purpose of this study was to determine if dental ages are more advanced in overweight children and influenced by genetic variation. Methods: Panoramic radiographs from 577 children were obtained. For performing genetic studies, an additional 236 subjects had panoramic radiographs and whole saliva samples collected. Genotyping of IGF, FGF, and FGFR markers was done. Dental age was determined in 177 patients utilizing Demerjian's method and panoramic radiographs. Skeletal maturation was determined in 28 patients using Baccetti's cervical vertebral maturation method on lateral cephalograms. PLINK was used to test for over-representation of alleles. Results:FGF7, FGF10, and FGF13 were significantly associated with obesity (P = 0.02). When dental age was considered, overweight and obesechildren are more likely to have dental ages more advanced than their chronological ages (P = 0.05). An excess of heterozygotes of FGF18rs4073716 was found in children with dental age more advanced than their chronological age (P=0.04). Conclusions: Overweight and obesechildren have dental ages more advanced than their chronological ages, and this occurrence may be influenced by genetic variation in FGF18.
Authors: Daniel S Sinden; Corey D Holman; Curtis J Bare; Xiaolu Sun; Aravind R Gade; David E Cohen; Geoffrey S Pitt Journal: FASEB J Date: 2019-07-24 Impact factor: 5.834