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Literature DB >> 3099168

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

S Dandekar, S Sukumar, H Zarbl, L J Young, R D Cardiff.

Abstract

Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 3099168 PMCID： PMC367178 DOI： 10.1128/mcb.6.11.4104-4108.1986

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

24 in total

1. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

2. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.

Authors: M Wigler; S Silverstein; L S Lee; A Pellicer; Y c Cheng; R Axel
Journal: Cell Date: 1977-05 Impact factor: 41.582

3. A new approach to mammary tumorigenesis in rodents.

Authors: K B DeOme; D Medina
Journal: Cancer Date: 1969-12 Impact factor: 6.860

4. The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study.

Authors: C W Daniel; K B De Ome; J T Young; P B Blair; L J Faulkin
Journal: Proc Natl Acad Sci U S A Date: 1968-09 Impact factor: 11.205

5. Influence of mammary tumor virus on the tumor-producing capabilities of nodule outgrowth free of mammary tumor virus.

Authors: D Medina; K B DeOme
Journal: J Natl Cancer Inst Date: 1968-06 Impact factor: 13.506

6. A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors: F L Graham; A J van der Eb
Journal: Virology Date: 1973-04 Impact factor: 3.616

7. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis.

Authors: M Quintanilla; K Brown; M Ramsden; A Balmain
Journal: Nature Date: 1986 Jul 3-9 Impact factor: 49.962

8. Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide.

Authors: C J Marshall; K H Vousden; D H Phillips
Journal: Nature Date: 1984 Aug 16-22 Impact factor: 49.962

9. Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma.

Authors: I Guerrero; A Villasante; P D'Eustachio; A Pellicer
Journal: Science Date: 1984-09-07 Impact factor: 47.728

10. A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

Authors: M H Kraus; Y Yuasa; S A Aaronson
Journal: Proc Natl Acad Sci U S A Date: 1984-09 Impact factor: 11.205

21 in total

1. Coordinated expression of intermediate biomarkers for tumorigenic transformation in RAS-transfected mouse mammary epithelial cells.

Authors: N T Telang; R Narayanan; H L Bradlow; M P Osborne
Journal: Breast Cancer Res Treat Date: 1991-08 Impact factor: 4.872

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

1. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

2. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.

3. A new approach to mammary tumorigenesis in rodents.

4. The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study.

5. Influence of mammary tumor virus on the tumor-producing capabilities of nodule outgrowth free of mammary tumor virus.

6. A new technique for the assay of infectivity of human adenovirus 5 DNA.

7. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis.

8. Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide.

9. Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma.

10. A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

1. Coordinated expression of intermediate biomarkers for tumorigenic transformation in RAS-transfected mouse mammary epithelial cells.

2. Chemopreventive efficacy of stampidine in a murine breast cancer model.

3. Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene.

4. Kinds and spectrum of mutations induced by 1-nitrosopyrene adducts during plasmid replication in human cells.

5. Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis.

6. Biologic and molecular characterization of two newly isolated ras-containing murine leukemia viruses.

Review 7. Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens.

Review 8. Genetic alterations in primary breast cancer.

Review 9. The preneoplastic phenotype in murine mammary tumorigenesis.

10. Acidic pH induces topoisomerase II-mediated DNA damage.