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Literature DB >> 30991457

Why does stress aggravate itch? A possible role of the amygdala.

Abstract

Stress is the exacerbating factor of itch across patients with chronic itch due to different origins. However, the precise mechanisms behind stress-induced exacerbation of itch remain unknown. Chronic stress induces hyperexcitability of the amygdala, the centre of emotional processing. Recent findings on the itch neuronal pathways support a pivotal role of the amygdala for itch processing. We hypothesized that itch is enhanced by stress through hyperexcitation of the amygdala. Modulation of amygdala activity, therefore, may have therapeutic potential in the treatment of chronic itch.

Entities: Chemical Disease Gene Species

Keywords: amygdala; anxiety; chronic itch; chronic stress; scratching

Year: 2019 PMID： 30991457 PMCID： PMC6800744 DOI： 10.1111/exd.13941

Source DB: PubMed Journal: Exp Dermatol ISSN： 0906-6705 Impact factor: 3.960

33 in total

1. Role of induced negative and positive emotions in sensitivity to itch and pain in women.

Authors: A I M van Laarhoven; A L Walker; O H Wilder-Smith; S Kroeze; P L C M van Riel; P C M van de Kerkhof; F W Kraaimaat; A W M Evers
Journal: Br J Dermatol Date: 2012-06-11 Impact factor: 9.302

Review 2. Neuroimaging studies of amygdala function in anxiety disorders.

Authors: Scott L Rauch; Lisa M Shin; Christopher I Wright
Journal: Ann N Y Acad Sci Date: 2003-04 Impact factor: 5.691

3. Relationship between itch and psychological status of patients with atopic dermatitis.

Authors: D Chrostowska-Plak; A Reich; J C Szepietowski
Journal: J Eur Acad Dermatol Venereol Date: 2012-05-23 Impact factor: 6.166

4. Effects of acute stressors on itch- and pain-related behaviors in rats.

Authors: Jessica Marie Spradley; Auva Davoodi; Mirela Iodi Carstens; Earl Carstens
Journal: Pain Date: 2012-07-05 Impact factor: 6.961

5. How stress triggers itch: a preliminary study of the mechanism of stress-induced pruritus using fMRI.

Authors: Hee Joo Kim; Jae Beom Park; Jong Hwan Lee; Il-Hwan Kim
Journal: Int J Dermatol Date: 2015-08-14 Impact factor: 2.736

6. Coping as mediator of the relationship between stress and itch in patients with atopic dermatitis: a regression and mediation analysis.

Authors: Christina Schut; Ulrike Weik; Natalia Tews; Uwe Gieler; Renate Deinzer; Jörg Kupfer
Journal: Exp Dermatol Date: 2014-11-18 Impact factor: 3.960

7. Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats.

Authors: Andrea Hetzel; J Amiel Rosenkranz
Journal: Neuropsychopharmacology Date: 2014-03-12 Impact factor: 7.853

Why does stress aggravate itch? A possible role of the amygdala.

1. Role of induced negative and positive emotions in sensitivity to itch and pain in women.

Review 2. Neuroimaging studies of amygdala function in anxiety disorders.

3. Relationship between itch and psychological status of patients with atopic dermatitis.

4. Effects of acute stressors on itch- and pain-related behaviors in rats.

5. How stress triggers itch: a preliminary study of the mechanism of stress-induced pruritus using fMRI.

6. Coping as mediator of the relationship between stress and itch in patients with atopic dermatitis: a regression and mediation analysis.

7. Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats.

8. Association of stress with symptoms of atopic dermatitis.

9. Adrenergic β2-receptor mediates itch hypersensitivity following heterotypic chronic stress in rats.

10. Encoding of danger by parabrachial CGRP neurons.

Review 1. THE SKIN MICROBIOTA AND ITCH: Is There a Link?

Review 2. The Skin Microbiota and Itch: Is There a Link?