Evan J Anderson1, John P DeVincenzo2, Eric A F Simões3, Leonard R Krilov4, Michael L Forbes5, Pia S Pannaraj6, Claudia M Espinosa7, Robert C Welliver8, Leslie I Wolkoff9, Ram Yogev10, Paul A Checchia11, Joseph B Domachowske12, Natasha Halasa13, Scott J McBride14, Veena R Kumar15, Kimmie K McLaurin15, Christopher P Rizzo15, Christopher S Ambrose15. 1. Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, Georgia. 2. Departments of Pediatrics and Microbiology, Immunology, and Biochemistry, University of Tennessee School of Medicine, Memphis, Tennessee. 3. Section of Pediatric Infectious Disease, University of Colorado School of Medicine, Colorado School of Public Health, Children's Hospital Colorado, Aurora, Colorado. 4. Division of Pediatric Infectious Disease, Children's Medical Center, NYU-Winthrop Hospital, Mineola, New York. 5. Pediatric Critical Care Medicine, Akron Children's Hospital, Akron, Ohio. 6. Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California, Keck School of Medicine, University of Southern California, Los Angeles, California. 7. Pediatric Infectious Diseases, University of Louisville, Louisville, Kentucky. 8. Pediatric Infectious Diseases, Children's Hospital at OU Medical Center, Oklahoma City, Oklahoma. 9. Division of Neonatology, Connecticut Children's Medical Center, Hartford, Connecticut. 10. Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 11. Cardiac Intensive Care, Texas Children's Hospital, Houston, Texas. 12. Pediatrics: Infectious Disease, SUNY Upstate Medical University, Syracuse, New York. 13. Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee. 14. United BioSource Corporation, Ann Arbor, Michigan. 15. AstraZeneca, Gaithersburg, Maryland.
Abstract
OBJECTIVE: The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. STUDY DESIGN: All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1-April 30) lasting ≥24 hours among preterm infants 29 to 35 wGA and aged <12 months who did not receive RSV IP within 35 days before onset of symptoms were identified and characterized. RESULTS: Results were similar across the two seasons. Among infants with community-acquired RSVH (N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge. CONCLUSION: Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. STUDY DESIGN: All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1-April 30) lasting ≥24 hours among preterm infants 29 to 35 wGA and aged <12 months who did not receive RSV IP within 35 days before onset of symptoms were identified and characterized. RESULTS: Results were similar across the two seasons. Among infants with community-acquired RSVH (N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge. CONCLUSION: Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Bryan O Nyawanda; Nancy A Otieno; Michael O Otieno; Gideon O Emukule; Godfrey Bigogo; Clayton O Onyango; Shirley Lidechi; Jeremiah Nyaundi; Gayle E Langley; Marc-Alain Widdowson; Sandra S Chaves Journal: J Infect Dis Date: 2022-06-15 Impact factor: 7.759