Francesco Petrella1,2, Samuele Frassoni3, Vincenzo Bagnardi3, Monica Casiraghi1, Daniela Brambilla4, Cristina Diotti1, Lorenzo Spaggiari1,2. 1. Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy. 2. Department of Oncology and Emato-oncology Università degli Studi di Milano, Milan, Italy. 3. Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. 4. Department of Data Management, European Institute of Oncology, Milan, Italy.
Abstract
BACKGROUND: Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease.The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes. METHODS: Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Preoperative patient characteristics were noted, including demographic information, operative details, pathologic information including histology and tumor stage according to the eighth edition of the tumor nodes metastases staging system, and the use of neoadjuvant or adjuvant treatments. RESULTS: Patients receiving the second pulmonary resection more than 24 months from the first procedure as well as patients receiving bilateral lobectomies had higher overall 3-, 5-, and 10-year survival rates compared with the others. CONCLUSION: Patients receiving the second resection more than 24 months from the first procedure have the best long-term results irrespective of the type of resection. Thieme. All rights reserved.
BACKGROUND:Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease.The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes. METHODS: Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Preoperative patient characteristics were noted, including demographic information, operative details, pathologic information including histology and tumor stage according to the eighth edition of the tumor nodes metastases staging system, and the use of neoadjuvant or adjuvant treatments. RESULTS:Patients receiving the second pulmonary resection more than 24 months from the first procedure as well as patients receiving bilateral lobectomies had higher overall 3-, 5-, and 10-year survival rates compared with the others. CONCLUSION:Patients receiving the second resection more than 24 months from the first procedure have the best long-term results irrespective of the type of resection. Thieme. All rights reserved.
Authors: Jennie K Choe; Amy Zhu; Alexander J Byun; Junting Zheng; Kay See Tan; Joe Dycoco; Manjit S Bains; Matthew J Bott; Robert J Downey; James Huang; James M Isbell; Daniela Molena; Valerie W Rusch; Bernard J Park; Gaetano Rocco; Smita Sihag; David R Jones; Prasad S Adusumilli Journal: JTO Clin Res Rep Date: 2022-06-18