Martin Rune Hassan Hansen1, Erik Jørs2, Annelli Sandbæk3, Henrik Albert Kolstad4, Jörg Schullehner5, Vivi Schlünssen6. 1. Section for Environment, Work and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100 København Ø, Denmark. Electronic address: martinrunehassanhansen@ph.au.dk. 2. Department of Occupational Medicine, Odense University Hospital, Kløvervænget 3, indgang 138, DK-5000 Odense C, Denmark. Electronic address: erik.joers@rsyd.dk. 3. Section of General Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital and Central Denmark Region, Hedeager 3, DK-8200 Aarhus N, Denmark. Electronic address: anesnd@rm.dk. 4. Department of Occupational Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 35, indgang C, DK-8200 Aarhus N, Denmark. Electronic address: henrkols@rm.dk. 5. National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building K, DK-8210 Aarhus V, Denmark; Geological Survey of Denmark and Greenland, C. F. Møllers Allé 8, DK-8000 Aarhus C, Denmark. Electronic address: jorg.schullehner@econ.au.dk. 6. Section for Environment, Work and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100 København Ø, Denmark. Electronic address: vs@ph.au.dk.
Abstract
OBJECTIVES: To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits. METHODS: Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language. INFORMATION SOURCES: Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies. Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively. FUNDING: The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment. REGISTRATION: PROSPERO CRD42017068861.
OBJECTIVES: To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits. METHODS: Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language. INFORMATION SOURCES: Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies. Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively. FUNDING: The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment. REGISTRATION: PROSPERO CRD42017068861.