Wilmer Silva-Caso1, Miguel Angel Aguilar-Luis2, Carlos Palomares-Reyes3, Fernando Mazulis3, Claudia Weilg3, Luis J Del Valle4, Jaquelin Espejo-Evaristo5, Fernando Soto-Febres6, Johanna Martins-Luna3, Juana Del Valle-Mendoza7. 1. School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Centro de Salud Las Palmas, Red de Salud Leoncio Prado, Ministerio de Salud, Huanuco, Peru. Electronic address: pcmewsil@upc.edu.pe. 2. School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Instituto de Investigación de Enfermedades Infecciosas, Lima, Peru; Instituto de Investigación Nutricional, Lima, Peru. 3. School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. 4. Centre d'Enginyeria Biotecnologica i Molecular (CEBIM), Departament d'Enginyeria Quıímica, ETSEIB, Universidad Politécnica de Catalunya (UPC), Barcelona Tech, Spain. 5. Puesto de Salud Alto San Juan de Tulumayo, Red de Salud Leoncio Prado, Ministerio de Salud, Huanuco, Peru. 6. Puesto de Salud Alto Pendencia, Red de Salud Leoncio Prado, Ministerio de Salud, Huanuco, Peru. 7. School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Instituto de Investigación Nutricional, Lima, Peru. Electronic address: juana.delvalle@upc.pe.
Abstract
INTRODUCTION: Oropouche fever is an under-reported and emerging infectious disease caused by Oropouche virus (OROV). Its incidence is under-estimated mainly due to clinical similarities with other endemic arboviral diseases and the lack of specific diagnostic tests. We report the first outbreak of Oropouche fever in a western region of the Peruvian Amazon in Huanuco, Peru. METHODS: A transversal study was carried out during an outbreak in the western Region of Huanuco, Peru between January and July of 2016. Blood samples of 268 patients with acute febrile syndrome were collected and analyzed for OROV via RT- PCR and genetic sequencing. RESULTS: Of all 268 patients, 46 (17%) cases tested positive for OROV. The most common symptoms reported were headache with a frequency of 87% (n = 40) followed by myalgia with 76% (n = 35), arthralgia with 65.2% (n = 30), retro-ocular pain 60.8% (n = 28) and hyporexia with 50% (n = 23). Some patients showed a clinical presentation suggestive of severe OROV infection, of which 4.3% (n = 2) had low platelet count, 8.6% (n = 4) had intense abdominal pain, and 2.1% (n = 1) had a presentation with thoracic pain. CONCLUSION: This study reports an outbreak of OROV in a region where this virus was not previously identified. The disease caused by OROV is an emerging, underdiagnosed infection that requires further research to determine its virulence, pathogenesis, host range and vectors involved in the urban and sylvatic cycles as well as identifying new genotypes to implement sensitive and specific diagnostic tools that can be applied to endemic regions.
INTRODUCTION:Oropouche fever is an under-reported and emerging infectious disease caused by Oropouche virus (OROV). Its incidence is under-estimated mainly due to clinical similarities with other endemic arboviral diseases and the lack of specific diagnostic tests. We report the first outbreak of Oropouche fever in a western region of the Peruvian Amazon in Huanuco, Peru. METHODS: A transversal study was carried out during an outbreak in the western Region of Huanuco, Peru between January and July of 2016. Blood samples of 268 patients with acute febrile syndrome were collected and analyzed for OROV via RT- PCR and genetic sequencing. RESULTS: Of all 268 patients, 46 (17%) cases tested positive for OROV. The most common symptoms reported were headache with a frequency of 87% (n = 40) followed by myalgia with 76% (n = 35), arthralgia with 65.2% (n = 30), retro-ocular pain 60.8% (n = 28) and hyporexia with 50% (n = 23). Some patients showed a clinical presentation suggestive of severe OROV infection, of which 4.3% (n = 2) had low platelet count, 8.6% (n = 4) had intense abdominal pain, and 2.1% (n = 1) had a presentation with thoracic pain. CONCLUSION: This study reports an outbreak of OROV in a region where this virus was not previously identified. The disease caused by OROV is an emerging, underdiagnosed infection that requires further research to determine its virulence, pathogenesis, host range and vectors involved in the urban and sylvatic cycles as well as identifying new genotypes to implement sensitive and specific diagnostic tools that can be applied to endemic regions.
Authors: Miguel Angel Aguilar-Luis; Juana Del Valle-Mendoza; Isabel Sandoval; Wilmer Silva-Caso; Fernando Mazulis; Hugo Carrillo-Ng; Yordi Tarazona-Castro; Johanna Martins-Luna; Ronald Aquino-Ortega; Isaac Peña-Tuesta; Angela Cornejo-Tapia; Luis J Del Valle Journal: BMC Res Notes Date: 2021-01-21
Authors: Hilda V Durango-Chavez; Carlos J Toro-Huamanchumo; Wilmer Silva-Caso; Johanna Martins-Luna; Miguel Angel Aguilar-Luis; Juana Del Valle-Mendoza; Zully M Puyen Journal: PLoS One Date: 2022-07-26 Impact factor: 3.752
Authors: Johanna Martins-Luna; Juana Del Valle-Mendoza; Wilmer Silva-Caso; Isabel Sandoval; Luis J Del Valle; Carlos Palomares-Reyes; Hugo Carrillo-Ng; Isaac Peña-Tuesta; Miguel Angel Aguilar-Luis Journal: BMC Res Notes Date: 2020-02-10
Authors: Juana Del Valle-Mendoza; Fernando Vasquez-Achaya; Miguel Angel Aguilar-Luis; Johanna Martins-Luna; Jorge Bazán-Mayra; Victor Zavaleta-Gavidia; Wilmer Silva-Caso; Hugo Carrillo-Ng; Yordi Tarazona-Castro; Ronald Aquino-Ortega; Luis J Del Valle Journal: BMC Res Notes Date: 2020-10-06