Literature DB >> 30991023

The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells.

Inge Van Der Werf1, Catriona Jamieson2.   

Abstract

A prevalent eukaryotic N6-methyladensosine (m6A) post-transcriptional mark can be "erased" by the m6A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML). In this issue of Cancer Cell, Huang et al. design small-molecule FTO inhibitors, FB23 and FB23-2, and demonstrate their potent inhibitory impact in AML models.
Copyright © 2019. Published by Elsevier Inc.

Entities:  

Year:  2019        PMID： 30991023     DOI： 10.1016/j.ccell.2019.03.011

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

Review 1.  The Key Role of RNA Modification in Breast Cancer.

Authors:  Yang Liu; Tong Zhu; Yi Jiang; Jiawen Bu; Xudong Zhu; Xi Gu
Journal:  Front Cell Dev Biol       Date:  2022-06-01

Review 2.  RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications.

Authors:  Chang Gu; Xin Shi; Chenyang Dai; Feng Shen; Gaetano Rocco; Jiafei Chen; Zhengyu Huang; Chunji Chen; Chuan He; Tao Huang; Chang Chen
Journal:  Innovation (Camb)       Date:  2020-11-04

Review 3.  Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases.

Authors:  Yazhen You; Yundong Fu; Mingjie Huang; Dandan Shen; Bing Zhao; Hongmin Liu; Yichao Zheng; Lihua Huang
Journal:  Int J Mol Sci       Date:  2022-05-22       Impact factor: 6.208

4.  Long Non-Coding RNA TUG1 Modulates Proliferation, Migration, And Invasion Of Acute Myeloid Leukemia Cells Via Regulating miR-370-3p/MAPK1/ERK.

Authors:  Gang Li; Peiming Zheng; Huiling Wang; Yushu Ai; Xiaohuan Mao
Journal:  Onco Targets Ther       Date:  2019-11-29       Impact factor: 4.147

Review 5.  Epigenetic Dysregulation at the Crossroad of Women's Cancer.

Authors:  Rakesh Kumar; Aswathy Mary Paul; Pranela Rameshwar; M Radhakrishna Pillai
Journal:  Cancers (Basel)       Date:  2019-08-16       Impact factor: 6.639

6.  TRIM25 contributes to the malignancy of acute myeloid leukemia and is negatively regulated by microRNA-137.

Authors:  Sheng Wang; Bang Shuo Zhang; Yi Yang; Ying Li; Jing Long Lv; Yu Cheng
Journal:  Open Med (Wars)       Date:  2020-12-24

Review 7.  The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers.

Authors:  Jin-Yan Wang; Li-Juan Chen; Ping Qiang
Journal:  Onco Targets Ther       Date:  2020-12-15       Impact factor: 4.147

Review 8.  Epitranscriptomics in Normal and Malignant Hematopoiesis.

Authors:  Crescenzio Francesco Minervini; Elisa Parciante; Luciana Impera; Luisa Anelli; Antonella Zagaria; Giorgina Specchia; Pellegrino Musto; Francesco Albano
Journal:  Int J Mol Sci       Date:  2020-09-09       Impact factor: 5.923

Review 9.  RNA N6 -methyladenosine modification in the lethal teamwork of cancer stem cells and the tumor immune microenvironment: Current landscape and therapeutic potential.

Authors:  Zhihui Zhang; Chaoqi Zhang; Yuejun Luo; Guochao Zhang; Peng Wu; Nan Sun; Jie He
Journal:  Clin Transl Med       Date:  2021-09
  9 in total

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