Context: Differential expression profiles of microRNAs have been reported in human obesity suggesting a miRNAs role in the development of obesity and associated disorders. Objective: To review circulating microRNAs (c-miRNAs) dysregulated in human obesity and to predict their possible target genes. Methods: We performed a systematic review on PubMed database (PROSPERO, CRD42017077742) for original works on c-miRNAs and human obesity and recorded c-miRNAs with differential expression profiles. Potential target genes and metabolic pathways for dysregulated miRNAs with at least two independent reports were searched using bioinformatic tools. Results: Twenty-two c-miRNAs are overexpressed, nine underexpressed and two c-miRNAs dysregulated in both directions in people with obesity compared to lean controls. Bioinformatic analyses suggest these c-miRNAs target on genes associated with fatty acid metabolism and PI3k/Akt pathway. Conclusion: Literature records 33 c-miRNAs confirmedly dysregulated in human obesity. Their predicted target genes are involved in pathways that could explain the development of obesity and its comorbidities. Further research will clarify the role of these miRNAs on metabolic diseases and their usefulness for the prognosis, prevention and treatment of obesity.
Context: Differential expression profiles of microRNAs have been reported in humanobesity suggesting a miRNAs role in the development of obesity and associated disorders. Objective: To review circulating microRNAs (c-miRNAs) dysregulated in humanobesity and to predict their possible target genes. Methods: We performed a systematic review on PubMed database (PROSPERO, CRD42017077742) for original works on c-miRNAs and humanobesity and recorded c-miRNAs with differential expression profiles. Potential target genes and metabolic pathways for dysregulated miRNAs with at least two independent reports were searched using bioinformatic tools. Results: Twenty-two c-miRNAs are overexpressed, nine underexpressed and two c-miRNAs dysregulated in both directions in people with obesity compared to lean controls. Bioinformatic analyses suggest these c-miRNAs target on genes associated with fatty acid metabolism and PI3k/Akt pathway. Conclusion: Literature records 33 c-miRNAs confirmedly dysregulated in humanobesity. Their predicted target genes are involved in pathways that could explain the development of obesity and its comorbidities. Further research will clarify the role of these miRNAs on metabolic diseases and their usefulness for the prognosis, prevention and treatment of obesity.
Authors: Andrea Maugeri; Martina Barchitta; Roberta Magnano San Lio; Giuliana Favara; Claudia La Mastra; Maria Clara La Rosa; Antonella Agodi Journal: Dis Markers Date: 2021-12-03 Impact factor: 3.434
Authors: Susana Sangiao-Alvarellos; Konstantinos Theofilatos; Temo Barwari; Clemens Gutmann; Kaloyan Takov; Bhawana Singh; Paula Juiz-Valiña; Bárbara María Varela-Rodríguez; Elena Outeiriño-Blanco; Elisa Duregotti; Anna Zampetaki; Lukas Lunger; Christoph Ebenbichler; Herbert Tilg; María Jesús García-Brao; Peter Willeit; Enrique Mena; Stefan Kiechl; Fernando Cordido; Manuel Mayr Journal: BMJ Open Diabetes Res Care Date: 2020-10