Literature DB >> 30990084

New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1.

Min-Jia Cao1, Tao Zhu1, Jing-Tang Liu1, Liang Ouyang2, Fan Yang1, Hou-Wen Lin1.   

Abstract

Two new sorbicillinoids, 13-hydroxy-dihydrotrichodermolide (1) and 10,11,27,28-tetrahydrotrisorbicillinone C (2), were isolated from the sponge-derived fungus Penicillium chrysogenum 581F1. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 2 displayed high affinities to target proteins GLP-1R (diabetes) and eEF2K (cancer) with Kd values of 0.0285 μM, 0.0162 μM for GLP-1R and 0.118 μM, 0.0746 μM for eEF2K, respectively.

Entities:  

Keywords:  Sponge-derived fungus; sorbicillinoid; trisorbicillinone

Year:  2019        PMID： 30990084     DOI： 10.1080/14786419.2019.1596099

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  5 in total

Review 1.  Recent Advances of Marine Sponge-Associated Microorganisms as a Source of Commercially Viable Natural Products.

Authors:  Tan Suet May Amelia; Ferr Angelus C Suaberon; Johanne Vad; Afiq Durrani Mohd Fahmi; Jonel P Saludes; Kesaven Bhubalan
Journal:  Mar Biotechnol (NY)       Date:  2022-05-14       Impact factor: 3.619

Review 2.  Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology.

Authors:  Francisco Fierro; Inmaculada Vaca; Nancy I Castillo; Ramón Ovidio García-Rico; Renato Chávez
Journal:  Microorganisms       Date:  2022-03-06

Review 3.  Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy.

Authors:  Bin Zhang; Jiamei Zou; Qiting Zhang; Ze Wang; Ning Wang; Shan He; Yufen Zhao; C Benjamin Naman
Journal:  Int J Mol Sci       Date:  2021-02-27       Impact factor: 5.923

4.  Structurally Various Sorbicillinoids From an Endophytic Fungus Acremonium citrinum SS-g13.

Authors:  Xiao-Ping Peng; Gang Li; Li-Mei Wang; Qi Wang; Cong Wang; Li-Xia Ji; Chen-Xi Cao; Guo-Feng Lin; Zu-Yang Jiang; Zhuo-Qian He; Pei Wang; Hong-Xiang Lou
Journal:  Front Microbiol       Date:  2022-03-23       Impact factor: 5.640

Review 5.  Recent Advances in Sorbicillinoids from Fungi and Their Bioactivities (Covering 2016-2021).

Authors:  Xuwen Hou; Xuping Zhang; Mengyao Xue; Zhitong Zhao; Huizhen Zhang; Dan Xu; Daowan Lai; Ligang Zhou
Journal:  J Fungi (Basel)       Date:  2022-01-07
  5 in total

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