Literature DB >> 30989559

The role of MAPK signaling pathway in formation of EMT in oral squamous carcinoma cells induced by TNF-α.

Xiao-Wei Zhao1, Jing-Ping Zhou1, Yu-Lan Bi1, Jia-Ying Wang1, Rui Yu1, Chao Deng1, Wei-Kang Wang1, Xian-Zhen Li1, Rui Huang1, Jili Zhang1, De-Tao Tao2.   

Abstract

To study the role of MAPK signaling pathway in the development of Epithelial-mesenchymal transition in oral squamous cell carcinoma induced by inflammatory factor TNF-α. After the action of TNF-α, the expression of JNK, ERK, P38 in MAPK signaling pathway increased and the expression of E-cadherin, Claudin1 decreased significantly compared to the normal control group. After the addition of corresponding inhibitor, the expression of JNK, ERK, P38 decreased and the expression of E-cadherin, Claudin1 increased compared with TNF-α group. TNF-α regulated the role of EMT in promoting the invasion and metastasis of oral squamous carcinoma cells through MAPK signaling pathway.

Entities:  

Keywords:  EMT; MAPK; Oral squamous cell carcinoma; TNF-α

Mesh：

Substances：

Year:  2019        PMID： 30989559     DOI： 10.1007/s11033-019-04772-0

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  12 in total

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1.  Identification and Development of Subtypes with Poor Prognosis in Gastric Cancer Based on Both Hypoxia and Immune Cell Infiltration.

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2.  Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway.

Authors:  Xiong Wu; Shuanglong Chen; Chuanhui Lu
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3.  Avenanthramide C Suppresses Matrix Metalloproteinase-9 Expression and Migration Through the MAPK/NF- κB Signaling Pathway in TNF-α-Activated HASMC Cells.

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Journal:  Front Pharmacol       Date:  2021-03-25       Impact factor: 5.810

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Review 5.  The Multiple Roles of CD147 in the Development and Progression of Oral Squamous Cell Carcinoma: An Overview.

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8.  TNF-α Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways.

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  8 in total

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