Hui-Ling Yang1, Hsin Chu2,3, Ching-Chiu Kao1,4, Huei-Ling Chiu5, Ing-Jy Tseng5, Philip Tseng6,7,8, Kuei-Ru Chou1,9,10. 1. School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan. 2. Institute of Aerospace and Undersea Medicine, School of Medicine, National Defense Medical Center, Taipei, Taiwan. 3. Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. 4. Department of Nursing, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 5. School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwan. 6. Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan. 7. Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan. 8. Brain and Consciousness Research Center, TMU - Shuang Ho Hospital, New Taipei City, Taiwan. 9. Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan. 10. Department of Nursing, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan.
Abstract
BACKGROUND:memory training is a potential intervention for retaining memory and reducing dementia risk in older adults with mild cognitive impairment (MCI). OBJECTIVE: this study examined the effect of virtual interactive working memory training (VIMT) in older adults with MCI. DESIGN: single-blind, two-arm parallel-group, randomised controlled design. SETTING: retirement homes, institutions, and communities. SUBJECTS: a total of 66 older adults with MCI were recruited (mean age: 78.5 ± 7.6 years). METHODS: participants were randomly assigned to the experimental group (VIMT, n = 33) or active control group (n = 33). The VIMT program used the CogniPlus (includes four training modules). Both groups attended 45 min sessions 3 times per week, a total of 36 sessions. The primary outcome was working memory; secondary outcomes were immediate memory, delayed memory, subjective memory complaints and global cognitive function. All variables were measured at pre-test, post-test, and 3-month follow-up. RESULTS: between group, the effect of working memory adjusted mean difference by 1.75 (95% CI: 0.56 to 2.94; P < 0.01) at post-test. The results were analysed by a generalised estimating equation, which indicated that VIMT group significantly improved working memory at post-test (P = 0.01) relative to the active control group. CONCLUSIONS: the applied VIMT program can enable older adults with MCI to maintain their working memory and reduce the rate of cognitive deterioration. TRIAL REGISTRATION: This trial was registered on ClinicalTrials.gov (no.: NCT02462135).
RCT Entities:
BACKGROUND: memory training is a potential intervention for retaining memory and reducing dementia risk in older adults with mild cognitive impairment (MCI). OBJECTIVE: this study examined the effect of virtual interactive working memory training (VIMT) in older adults with MCI. DESIGN: single-blind, two-arm parallel-group, randomised controlled design. SETTING: retirement homes, institutions, and communities. SUBJECTS: a total of 66 older adults with MCI were recruited (mean age: 78.5 ± 7.6 years). METHODS:participants were randomly assigned to the experimental group (VIMT, n = 33) or active control group (n = 33). The VIMT program used the CogniPlus (includes four training modules). Both groups attended 45 min sessions 3 times per week, a total of 36 sessions. The primary outcome was working memory; secondary outcomes were immediate memory, delayed memory, subjective memory complaints and global cognitive function. All variables were measured at pre-test, post-test, and 3-month follow-up. RESULTS: between group, the effect of working memory adjusted mean difference by 1.75 (95% CI: 0.56 to 2.94; P < 0.01) at post-test. The results were analysed by a generalised estimating equation, which indicated that VIMT group significantly improved working memory at post-test (P = 0.01) relative to the active control group. CONCLUSIONS: the applied VIMT program can enable older adults with MCI to maintain their working memory and reduce the rate of cognitive deterioration. TRIAL REGISTRATION: This trial was registered on ClinicalTrials.gov (no.: NCT02462135).
Authors: Angie A Diaz Baquero; Manuel A Franco-Martín; Esther Parra Vidales; José Miguel Toribio-Guzmán; Yolanda Bueno-Aguado; Fernando Martínez Abad; María V Perea Bartolomé; Aysan Mahmoudi Asl; Henriëtte G van der Roest Journal: J Alzheimers Dis Date: 2022 Impact factor: 4.472