Literature DB >> 3098892

The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes.

D J Paterson, J R Green, W A Jefferies, M Puklavec, A F Williams.   

Abstract

A monoclonal antibody called MRC OX-44 is described that labels all myeloid cells and peripheral lymphoid cells but only 12% of thymocytes. The OX-44+ thymic cells include most if not all cells found in the medulla but only a small fraction of the cortical cells. Together with CD4 and CD8 antigens, seven subsets of thymic cell were defined and it was notable that most CD4- CD8- cells were OX-44+ whereas almost all CD4+ CD8+ cells were OX-44-. In functional tests, the OX-44+ cells accounted for all proliferation by thymocytes when stimulated by allogeneic spleen cells or concanavalin A plus growth factors and OX-44- cells were completely negative in these assays. Also, in tests for thymopoiesis after intra-thymic injection of cells, all activity was OX-44+. It seems possible that the OX-44+ set may include all functionally relevant cells in the rat thymus.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3098892      PMCID： PMC2188261          DOI： 10.1084/jem.165.1.1

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  32 in total

1.  Regulation of cellular and humoral immune responses by T-cell subclasses.

Authors:  H Cantor; E A Boyse
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

2.  Separation of functional subsets of human T cells by a monoclonal antibody.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

Review 3.  T cell subsets and the recognition of MHC class.

Authors:  S L Swain
Journal:  Immunol Rev       Date:  1983       Impact factor: 12.988

4.  Fluorescence analysis and anatomic distribution of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200.

Authors:  W van Ewijk; P L van Soest; G J van den Engh
Journal:  J Immunol       Date:  1981-12       Impact factor: 5.422

5.  Differences in the surface proteins of mouse B and T cells.

Authors:  I S Trowbridge; P Ralph; M J Bevan
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

6.  T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody.

Authors:  R A White; D W Mason; A F Williams; G Galfre; C Milstein
Journal:  J Exp Med       Date:  1978-09-01       Impact factor: 14.307

7.  The toleration of rat thymocytes to xenogeneic erythrocytes: kinetics of induction and recovery.

Authors:  J V Bunce; D W Mason
Journal:  Eur J Immunol       Date:  1981-11       Impact factor: 5.532

8.  Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus.

Authors:  T Fukumoto; W R McMaster; A F Williams
Journal:  Eur J Immunol       Date:  1982-03       Impact factor: 5.532

9.  DNA synthesis in purified populations of avian erythroid cells.

Authors:  A F Williams
Journal:  J Cell Sci       Date:  1972-01       Impact factor: 5.285

10.  Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of "mature" thymocytes as analyzed by monoclonal antibodies and flow microfluorometry.

Authors:  R Ceredig; A L Glasebrook; H R MacDonald
Journal:  J Exp Med       Date:  1982-02-01       Impact factor: 14.307
View more
  23 in total

1.  Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells.

Authors:  G M Bell; J B Bolen; J B Imboden
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

2.  Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

Authors:  A D Beyers; L L Spruyt; A F Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

3.  The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens.

Authors:  P Angelisová; C Vlcek; I Stefanová; M Lipoldová; V Horejsí
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

4.  T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications.

Authors:  P A Lazo; A J Klein-Szanto; P N Tsichlis
Journal:  J Virol       Date:  1990-08       Impact factor: 5.103

5.  Analysis of T cell receptor beta chains in rat thymus, and rat C alpha and C beta sequences.

Authors:  M Morris; A N Barclay; A F Williams
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

6.  The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation.

Authors:  A Bellacosa; P A Lazo; S E Bear; P N Tsichlis
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272

7.  Adoptively transferred experimental allergic encephalomyelitis in chimeric rats: identification of transferred cells in the lesions of the central nervous system.

Authors:  Y Matsumoto; M Fujiwara
Journal:  Immunology       Date:  1988-09       Impact factor: 7.397

8.  Recovery from chemically induced thymus atrophy starts with CD4- CD8- CD2high TcR alpha beta-/low thymocytes and results in an increased formation of CD4- CD8- TcR alpha beta high thymocytes.

Authors:  R H Pieters; M Bol; B W Lam; W Seinen; N Bloksma; A H Penninks
Journal:  Immunology       Date:  1993-04       Impact factor: 7.397

9.  Selective inhibition of immature CD4-CD8+ thymocyte proliferation, but not differentiation, by the thymus atrophy-inducing compound di-n-butyltin dichloride.

Authors:  R H Pieters; M Bol; T Ariëns; P Punt; W Seinen; N Bloksma; A H Penninks
Journal:  Immunology       Date:  1994-02       Impact factor: 7.397

10.  Ontogeny of rat thymic dendritic cells.

Authors:  A Vicente; A Varas; L Alonso; M Gómez de Moral; A G Zapata
Journal:  Immunology       Date:  1994-05       Impact factor: 7.397
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.