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Literature DB >> 30988507

Resolution of a complex crisis at DNA 3' termini.

Shan Yan¹.

Abstract

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Ribonucleotides
DNA

Year: 2019 PMID： 30988507 PMCID： PMC6549488 DOI： 10.1038/s41594-019-0215-0

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

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19 in total

1. Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III.

Authors: M Z Hadi; D M Wilson
Journal: Environ Mol Mutagen Date: 2000 Impact factor: 3.216

2. APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability.

Authors: Jinchao Li; Wenjie Liang; Yan Li; Weiqiang Qian
Journal: Plant Cell Date: 2018-08-22 Impact factor: 11.277

3. Apurinic endonuclease activity of yeast Apn2 protein.

Authors: I Unk; L Haracska; R E Johnson; S Prakash; L Prakash
Journal: J Biol Chem Date: 2000-07-21 Impact factor: 5.157

4. Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen.

Authors: D Tsuchimoto; Y Sakai; K Sakumi; K Nishioka; M Sasaki; T Fujiwara; Y Nakabeppu
Journal: Nucleic Acids Res Date: 2001-06-01 Impact factor: 16.971

5. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.

Authors: R E Johnson; C A Torres-Ramos; T Izumi; S Mitra; S Prakash; L Prakash
Journal: Genes Dev Date: 1998-10-01 Impact factor: 11.361

Resolution of a complex crisis at DNA 3' termini.

1. Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III.

2. APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability.

3. Apurinic endonuclease activity of yeast Apn2 protein.

4. Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen.

5. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.

6. APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

7. Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs.

8. APE2 promotes DNA damage response pathway from a single-strand break.

9. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

10. Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms.

Review 1. Function and molecular mechanisms of APE2 in genome and epigenome integrity.

2. APE1 senses DNA single-strand breaks for repair and signaling.