Literature DB >> 30988148

Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study.

Wei Zhao1,2, Evelyne Jacqz-Aigrain3,4, Xin-Mei Yang5, Stephanie Leroux6,7, Thomas Storme6, Dao-Lun Zhang6, Tiphaine Adam de Beaumais8, Hai-Yan Shi5, Yi-Lei Yang5, Xiao-Ling Wang9.   

Abstract

We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  caspofungin; children; developmental pharmacokinetics; dose

Mesh：

Substances：

Year:  2019        PMID： 30988148      PMCID： PMC6591648          DOI： 10.1128/AAC.00248-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide.

Authors:  Karl Brendel; Emmanuelle Comets; Céline Laffont; Christian Laveille; France Mentré
Journal:  Pharm Res       Date:  2006-08-12       Impact factor: 4.200

Review 2.  Advances in antifungal therapy.

Authors:  Carole A Sable; Kim M Strohmaier; Jeffrey A Chodakewitz
Journal:  Annu Rev Med       Date:  2008       Impact factor: 13.739

3.  Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method.

Authors:  Andrew C Hooker; Christine E Staatz; Mats O Karlsson
Journal:  Pharm Res       Date:  2007-07-06       Impact factor: 4.200

4.  Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models.

Authors:  Martin Bergstrand; Andrew C Hooker; Johan E Wallin; Mats O Karlsson
Journal:  AAPS J       Date:  2011-02-08       Impact factor: 4.009

5.  Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents.

Authors:  Thomas J Walsh; Peter C Adamson; Nita L Seibel; Patricia M Flynn; Michael N Neely; Cindy Schwartz; Aziza Shad; Sheldon L Kaplan; Maureen M Roden; Julie A Stone; Alisha Miller; Susan K Bradshaw; Susan X Li; Carole A Sable; Nicholas A Kartsonis
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

6.  A microscale HPLC-UV method for the determination of latamoxef in plasma: An adapted method for therapeutic drug monitoring in neonates.

Authors:  Qian Dong; Hai-Yan Shi; Chen Kou; Xin Huang; A-Dong Shen; Wei Zhao
Journal:  Biomed Chromatogr       Date:  2018-04-17       Impact factor: 1.902

7.  Quantitation of azoles and echinocandins in compartments of peripheral blood by liquid chromatography-tandem mass spectrometry.

Authors:  Fedja Farowski; Oliver A Cornely; Jörg J Vehreschild; Pia Hartmann; Tim Bauer; Angela Steinbach; Maria J G T Rüping; Carsten Müller
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

Review 8.  A clinical review of echinocandins in pediatric patients.

Authors:  Heather L VandenBussche; Dean A Van Loo
Journal:  Ann Pharmacother       Date:  2009-12-15       Impact factor: 3.154

9.  Pharmacokinetics and safety of caspofungin in older infants and toddlers.

Authors:  Michael Neely; Hasan S Jafri; Nita Seibel; Katherine Knapp; Peter C Adamson; Susan K Bradshaw; Kim M Strohmaier; Peng Sun; Sheng Bi; Marissa Fallon Dockendorf; Julie A Stone; Nicholas A Kartsonis
Journal:  Antimicrob Agents Chemother       Date:  2008-12-29       Impact factor: 5.191

10.  Factors influencing caspofungin plasma concentrations in patients of a surgical intensive care unit.

Authors:  T H Nguyen; T Hoppe-Tichy; H K Geiss; A C Rastall; S Swoboda; J Schmidt; M A Weigand
Journal:  J Antimicrob Chemother       Date:  2007-05-24       Impact factor: 5.790
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  2 in total

Review 1.  Administration and Dosing of Systemic Antifungal Agents in Pediatric Patients.

Authors:  Kevin J Downes; Brian T Fisher; Nicole R Zane
Journal:  Paediatr Drugs       Date:  2020-04       Impact factor: 3.022

2.  Population Pharmacokinetics of Caspofungin and Dosing Optimization in Children With Allogeneic Hematopoietic Stem Cell Transplantation.

Authors:  Chang-He Niu; Hua Xu; Liu-Liu Gao; Ying-Ming Nie; Li-Peng Xing; Li-Peng Yu; San-Lan Wu; Yang Wang
Journal:  Front Pharmacol       Date:  2020-03-02       Impact factor: 5.810
  2 in total

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